4s2v

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "4s2v" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
+
==E. coli RppH structure, KI soak==
-
 
+
<StructureSection load='4s2v' size='340' side='right' caption='[[4s2v]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-
The entry 4s2v is ON HOLD
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[4s2v]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S2V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4S2V FirstGlance]. <br>
-
Authors: Vasilyev, N., Serganov, A.
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
-
 
+
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4s2w|4s2w]], [[4s2x|4s2x]], [[4s2y|4s2y]]</td></tr>
-
Description: E. coli RppH structure, KI soak
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s2v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4s2v RCSB], [http://www.ebi.ac.uk/pdbsum/4s2v PDBsum]</span></td></tr>
-
[[Category: Unreleased Structures]]
+
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/RPPH_ECOLI RPPH_ECOLI]] Master regulator of 5'-dependent mRNA decay. Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage. Preferentially hydrolyzes diadenosine penta-phosphate with ATP as one of the reaction products. Also able to hydrolyze diadenosine hexa- and tetra-phosphate. Has no activity on diadenosine tri-phosphate, ADP-ribose, NADH and UDP-glucose. In the meningitis causing strain E.coli K1, has been shown to play a role in HBMEC (human brain microvascular endothelial cells) invasion in vitro.<ref>PMID:10760174</ref> <ref>PMID:18202662</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Serganov, A]]
[[Category: Serganov, A]]
[[Category: Vasilyev, N]]
[[Category: Vasilyev, N]]
 +
[[Category: Hydrolase]]
 +
[[Category: Nudix hydrolase]]
 +
[[Category: Rna pyrophosphohydrolase]]

Revision as of 12:00, 12 February 2015

E. coli RppH structure, KI soak

4s2v, resolution 1.70Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools