4txp

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'''Unreleased structure'''
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==Crystal structure of LIP5 N-terminal domain==
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<StructureSection load='4txp' size='340' side='right' caption='[[4txp]], [[Resolution|resolution]] 3.01&Aring;' scene=''>
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The entry 4txp is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4txp]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TXP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TXP FirstGlance]. <br>
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Authors: Vild, C.J., Xu, Z.
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4txq|4txq]], [[4txr|4txr]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4txp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4txp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4txp RCSB], [http://www.ebi.ac.uk/pdbsum/4txp PDBsum]</span></td></tr>
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Description: Crystal structure of LIP5 N-terminal domain
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</table>
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[[Category: Unreleased Structures]]
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== Function ==
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[[http://www.uniprot.org/uniprot/VTA1_HUMAN VTA1_HUMAN]] Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). Involved in HIV-1 budding.<ref>PMID:15644320</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Vild, C J]]
[[Category: Xu, Z]]
[[Category: Xu, Z]]
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[[Category: Vild, C.J]]
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[[Category: Escrt]]
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[[Category: Mit]]
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[[Category: Mit domain]]
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[[Category: Protein transport]]

Revision as of 12:01, 12 February 2015

Crystal structure of LIP5 N-terminal domain

4txp, resolution 3.01Å

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