4u7y
From Proteopedia
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| - | ''' | + | ==Structure of the complex of VPS4B MIT and IST1 MIM== |
| - | + | <StructureSection load='4u7y' size='340' side='right' caption='[[4u7y]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4u7y]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U7Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U7Y FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4u7e|4u7e]], [[4u7i|4u7i]]</td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Vesicle-fusing_ATPase Vesicle-fusing ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.6 3.6.4.6] </span></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u7y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u7y RCSB], [http://www.ebi.ac.uk/pdbsum/4u7y PDBsum]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: Guo, E | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/VPS4B_HUMAN VPS4B_HUMAN]] Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses).<ref>PMID:11563910</ref> <ref>PMID:14505570</ref> <ref>PMID:18687924</ref> [[http://www.uniprot.org/uniprot/IST1_HUMAN IST1_HUMAN]] Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells.<ref>PMID:19129479</ref> <ref>PMID:19129480</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Vesicle-fusing ATPase]] | ||
| + | [[Category: Guo, E Z]] | ||
[[Category: Xu, Z]] | [[Category: Xu, Z]] | ||
| + | [[Category: Complex]] | ||
| + | [[Category: Mim1]] | ||
Revision as of 12:02, 12 February 2015
Structure of the complex of VPS4B MIT and IST1 MIM
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Categories: Vesicle-fusing ATPase | Guo, E Z | Xu, Z | Complex | Mim1
