4w8n
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | ''' | + | ==The crystal structure of hemagglutinin from a swine influenza virus (A/swine/Missouri/2124514/2006)== |
| - | + | <StructureSection load='4w8n' size='340' side='right' caption='[[4w8n]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4w8n]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W8N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4W8N FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4w8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w8n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4w8n RCSB], [http://www.ebi.ac.uk/pdbsum/4w8n PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[ | + | == Function == |
| - | [[ | + | [[http://www.uniprot.org/uniprot/A9YN66_9INFA A9YN66_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324][SAAS:SAAS00145386] |
| - | [[Category: Carney, P | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Carney, P J]] | ||
[[Category: Stevens, J]] | [[Category: Stevens, J]] | ||
| - | [[Category: Tumpey, T | + | [[Category: Tumpey, T M]] |
| + | [[Category: Yang, H]] | ||
| + | [[Category: Hemagglutinin]] | ||
| + | [[Category: Influenza virus]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 12:03, 12 February 2015
The crystal structure of hemagglutinin from a swine influenza virus (A/swine/Missouri/2124514/2006)
| |||||||||||
