4x4w
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Crystal structure of the full-length human mitochondrial CCA-adding enzyme== |
| - | + | <StructureSection load='4x4w' size='340' side='right' caption='[[4x4w]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4x4w]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X4W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X4W FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/CCA_tRNA_nucleotidyltransferase CCA tRNA nucleotidyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.72 2.7.7.72] </span></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x4w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4x4w RCSB], [http://www.ebi.ac.uk/pdbsum/4x4w PDBsum]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TRNT1_HUMAN TRNT1_HUMAN]] Isoform 1: Adds and repairs the conserved 3'-CCA sequence necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, using CTP and ATP as substrates.<ref>PMID:17204286</ref> Isoform 2: Adds 2 C residues (CC-) to the 3' terminus of tRNA molecules instead of a complete CCA end as isoform 1 does (in vitro).<ref>PMID:17204286</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: CCA tRNA nucleotidyltransferase]] | ||
[[Category: Joshua-Tor, L]] | [[Category: Joshua-Tor, L]] | ||
| - | [[Category: Kuhn, C | + | [[Category: Kuhn, C D]] |
| + | [[Category: Cca-adding enzyme]] | ||
| + | [[Category: Ncrna]] | ||
| + | [[Category: Non-coding rna]] | ||
| + | [[Category: Nucleotidyltransferase]] | ||
| + | [[Category: Protein-rna complex]] | ||
| + | [[Category: Rna binding protein]] | ||
| + | [[Category: Trna]] | ||
Revision as of 12:05, 12 February 2015
Crystal structure of the full-length human mitochondrial CCA-adding enzyme
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