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4xwa
From Proteopedia
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| - | ''' | + | ==TMK from S.aureus in complex with the Piperidinyl Thymine class inhibitor with a C5 ethyl-amine== |
| - | + | <StructureSection load='4xwa' size='340' side='right' caption='[[4xwa]], [[Resolution|resolution]] 1.89Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4xwa]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XWA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XWA FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=43N:2-(3-CHLOROPHENOXY)-6-(ETHYLAMINO)-4-[(R)-[(3S)-3-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)PIPERIDIN-1-YL](PHENYL)METHYL]BENZOIC+ACID'>43N</scene></td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9] </span></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xwa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xwa RCSB], [http://www.ebi.ac.uk/pdbsum/4xwa PDBsum]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: Olivier, N | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/KTHY_STAA1 KTHY_STAA1]] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: DTMP kinase]] | ||
| + | [[Category: Olivier, N B]] | ||
| + | [[Category: Antibacterial]] | ||
| + | [[Category: Kinase]] | ||
| + | [[Category: Piperidine]] | ||
| + | [[Category: Thymidine]] | ||
| + | [[Category: Tmk]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 12:07, 12 February 2015
TMK from S.aureus in complex with the Piperidinyl Thymine class inhibitor with a C5 ethyl-amine
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Categories: DTMP kinase | Olivier, N B | Antibacterial | Kinase | Piperidine | Thymidine | Tmk | Transferase
