4elt
From Proteopedia
(Difference between revisions)
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| - | + | ==Snapshot of the large fragment of DNA polymerase I from Thermus Aquaticus processing modified pyrimidines== | |
| - | + | <StructureSection load='4elt' size='340' side='right' caption='[[4elt]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4elt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ELT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ELT FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0R5:2-DEOXY-5-[(4-ETHYNYLPHENYL)ETHYNYL]URIDINE+5-(TETRAHYDROGEN+TRIPHOSPHATE)'>0R5</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOC:2,3-DIDEOXYCYTIDINE-5-MONOPHOSPHATE'>DOC</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ojs|3ojs]], [[3oju|3oju]], [[4elu|4elu]], [[4elv|4elv]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">polA, pol1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=271 Thermus aquaticus])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4elt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4elt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4elt RCSB], [http://www.ebi.ac.uk/pdbsum/4elt PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Modified nucleotides play a paramount role in many cutting-edge biomolecular techniques. The present structural study highlights the plasticity and flexibility of the active site of a DNA polymerase while incorporating non-polar "Click-able" nucleotide analogs and emphasizes new insights into rational design guidelines for modified nucleotides. | ||
| - | + | Interactions of non-polar and "Click-able" nucleotides in the confines of a DNA polymerase active site.,Obeid S, Busskamp H, Welte W, Diederichs K, Marx A Chem Commun (Camb). 2012 Aug 28;48(67):8320-2. Epub 2012 Jul 6. PMID:22766607<ref>PMID:22766607</ref> | |
| - | + | ||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[DNA polymerase|DNA polymerase]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: DNA-directed DNA polymerase]] | [[Category: DNA-directed DNA polymerase]] | ||
[[Category: Thermus aquaticus]] | [[Category: Thermus aquaticus]] | ||
| - | [[Category: Diederichs, K | + | [[Category: Diederichs, K]] |
| - | [[Category: Marx, A | + | [[Category: Marx, A]] |
| - | [[Category: Obeid, S | + | [[Category: Obeid, S]] |
[[Category: A family]] | [[Category: A family]] | ||
[[Category: Dna polymerase]] | [[Category: Dna polymerase]] | ||
Revision as of 07:16, 15 February 2015
Snapshot of the large fragment of DNA polymerase I from Thermus Aquaticus processing modified pyrimidines
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