4bg2
From Proteopedia
(Difference between revisions)
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| - | + | ==X-ray Crystal Structure of PatF from Prochloron didemni== | |
| - | + | <StructureSection load='4bg2' size='340' side='right' caption='[[4bg2]], [[Resolution|resolution]] 2.13Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4bg2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Prochloron_didemni Prochloron didemni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BG2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BG2 FirstGlance]. <br> | ||
| + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bg2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bg2 RCSB], [http://www.ebi.ac.uk/pdbsum/4bg2 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Patellamides are macrocyclic peptides with potent biological effects and are a subset of the cyanobactins. Cyanobactins are natural products that are produced by a series of enzymatic transformations and a common modification is the addition of a prenyl group. Puzzlingly, the pathway for patellamides in Prochloron didemni contains a gene, patF, with homology to prenylases, but patellamides are not themselves prenylated. The structure of the protein PatF was cloned, expressed, purified and determined. Prenylase activity could not be demonstrated for the protein, and examination of the structure revealed changes in side-chain identity at the active site. It is suggested that these changes have inactivated the protein. Attempts to mutate these residues led to unfolded protein. | ||
| - | + | Structure of PatF from Prochloron didemni.,Bent AF, Koehnke J, Houssen WE, Smith MC, Jaspars M, Naismith JH Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jun;69(Pt 6):618-23. doi: , 10.1107/S1744309113012931. Epub 2013 May 23. PMID:23722837<ref>PMID:23722837</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Prochloron didemni]] | [[Category: Prochloron didemni]] | ||
| - | [[Category: Bent, A F | + | [[Category: Bent, A F]] |
| - | [[Category: Houssen, W E | + | [[Category: Houssen, W E]] |
| - | [[Category: Jaspars, M | + | [[Category: Jaspars, M]] |
| - | [[Category: Koehnke, J | + | [[Category: Koehnke, J]] |
| - | [[Category: Naismith, J H | + | [[Category: Naismith, J H]] |
| - | [[Category: Smith, M C.M | + | [[Category: Smith, M C.M]] |
[[Category: Cyanobactin]] | [[Category: Cyanobactin]] | ||
[[Category: Natural product]] | [[Category: Natural product]] | ||
Revision as of 07:39, 15 February 2015
X-ray Crystal Structure of PatF from Prochloron didemni
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