4mj9
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mj9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mj9 RCSB], [http://www.ebi.ac.uk/pdbsum/4mj9 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mj9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mj9 RCSB], [http://www.ebi.ac.uk/pdbsum/4mj9 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The crystal structure of the ruthenium DNA 'light-switch' complex Lambda-[Ru(TAP)2(11-Cl-dppz)](2+) (TAP=tetraazaphenanthrene, dppz=dipyrido[3,2-a':2',3'-c]phenazine) bound to the oligonucleotide duplex d(TCGGCGCCGA)2 is reported. The synthesis of the racemic ruthenium complex is described for the first time, and the racemate was used in this study. The crystal structure, at atomic resolution (1.0 A), shows one ligand as a wedge in the minor groove, resulting in the 51( degrees ) kinking of the double helix, as with the parent Lambda-[Ru(TAP)2(dppz)](2+). Each complex binds to one duplex by intercalation of the dppz ligand and also by semi-intercalation of one of the orthogonal TAP ligands into a second symmetrically equivalent duplex. The 11-chloro substituent binds with the major component (66%) oriented with the 11-chloro substituent on the purine side of the terminal step of the duplex. | ||
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| + | Preferred orientation in an angled intercalation site of a chloro-substituted {Lambda}-[Ru(TAP)2(dppz)]2+ complex bound to d(TCGGCGCCGA)2.,Hall JP, Beer H, Buchner K, Cardin DJ, Cardin CJ Philos Trans A Math Phys Eng Sci. 2013 Jun 17;371(1995):20120525. doi:, 10.1098/rsta.2012.0525. Print 2013. PMID:23776304<ref>PMID:23776304</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 07:17, 18 February 2015
lambda-[Ru(TAP)2(dppz-10-Me)]2+ bound to a synthetic DNA oligomer
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