This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2q1b
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:2q1b.jpg|left|200px]] | + | [[Image:2q1b.jpg|left|200px]] |
| - | + | ||
| - | '''Carbonic Anhydrase II in Complex with Saccharin''' | + | {{Structure |
| + | |PDB= 2q1b |SIZE=350|CAPTION= <scene name='initialview01'>2q1b</scene>, resolution 1.70Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene> and <scene name='pdbligand=LSA:1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE'>LSA</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Carbonic Anhydrase II in Complex with Saccharin''' | ||
| + | |||
==Disease== | ==Disease== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2Q1B is a [ | + | 2Q1B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q1B OCA]. |
==Reference== | ==Reference== | ||
| - | Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste., Kohler K, Hillebrecht A, Schulze Wischeler J, Innocenti A, Heine A, Supuran CT, Klebe G, Angew Chem Int Ed Engl. 2007;46(40):7697-9. PMID:[http:// | + | Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste., Kohler K, Hillebrecht A, Schulze Wischeler J, Innocenti A, Heine A, Supuran CT, Klebe G, Angew Chem Int Ed Engl. 2007;46(40):7697-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17705204 17705204] |
[[Category: Carbonate dehydratase]] | [[Category: Carbonate dehydratase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| Line 25: | Line 34: | ||
[[Category: twisted beta-sheet]] | [[Category: twisted beta-sheet]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:20:30 2008'' |
Revision as of 16:20, 20 March 2008
| |||||||
| , resolution 1.70Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , and | ||||||
| Activity: | Carbonate dehydratase, with EC number 4.2.1.1 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Carbonic Anhydrase II in Complex with Saccharin
Disease
Known disease associated with this structure: Osteopetrosis, autosomal recessive 3, with renal tubular acidosis OMIM:[611492]
About this Structure
2Q1B is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste., Kohler K, Hillebrecht A, Schulze Wischeler J, Innocenti A, Heine A, Supuran CT, Klebe G, Angew Chem Int Ed Engl. 2007;46(40):7697-9. PMID:17705204
Page seeded by OCA on Thu Mar 20 18:20:30 2008
Categories: Carbonate dehydratase | Homo sapiens | Single protein | Heine, A. | Klebe, G. | Koehler, K. | BEZ | HG | LSA | ZN | 10-stranded | Lyase | Twisted beta-sheet
