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| - | ==Neuronal calcium sensor (NCS-1)from Rattus norvegicus==
| + | #REDIRECT [[5aeq]] This PDB entry is obsolete and replaced by 5aeq |
| - | <StructureSection load='2yov' size='340' side='right' caption='[[2yov]], [[Resolution|resolution]] 1.95Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[2yov]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YOV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YOV FirstGlance]. <br>
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| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2you|2you]]</td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yov OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yov RCSB], [http://www.ebi.ac.uk/pdbsum/2yov PDBsum]</span></td></tr>
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| - | </table>
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/NCS1_RAT NCS1_RAT]] Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel.<ref>PMID:17502602</ref>
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Rattus norvegicus]]
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| - | [[Category: Burgoyne, R]]
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| - | [[Category: Derrick, J P]]
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| - | [[Category: Karuppiah, V]]
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| - | [[Category: Lian, L Y]]
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| - | [[Category: Pandalaneni, S]]
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| - | [[Category: Saleem, M]]
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| - | [[Category: Calcium-binding protein]]
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