5aeq
From Proteopedia
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| - | ''' | + | ==Neuronal calcium sensor (NCS-1)from Rattus norvegicus== |
| - | + | <StructureSection load='5aeq' size='340' side='right' caption='[[5aeq]], [[Resolution|resolution]] 1.95Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5aeq]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2yov 2yov]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AEQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AEQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5aer|5aer]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aeq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aeq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5aeq RCSB], [http://www.ebi.ac.uk/pdbsum/5aeq PDBsum]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NCS1_RAT NCS1_RAT]] Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel.<ref>PMID:17502602</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Burgoyne, R]] | ||
| + | [[Category: Derrick, J P]] | ||
[[Category: Karuppiah, V]] | [[Category: Karuppiah, V]] | ||
| + | [[Category: Lian, L Y]] | ||
[[Category: Pandalaneni, S]] | [[Category: Pandalaneni, S]] | ||
| - | [[Category: Lian, L.Y]] | ||
[[Category: Saleem, M]] | [[Category: Saleem, M]] | ||
| - | [[Category: | + | [[Category: Calcium sensor]] |
| - | [[Category: | + | [[Category: Signaling protein]] |
Revision as of 12:53, 18 February 2015
Neuronal calcium sensor (NCS-1)from Rattus norvegicus
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