5aer
From Proteopedia
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| - | ''' | + | ==Neuronal calcium sensor-1 (NCS-1)from Rattus norvegicus complex with D2 dopamine receptor peptide from Homo sapiens== |
| - | + | <StructureSection load='5aer' size='340' side='right' caption='[[5aer]], [[Resolution|resolution]] 2.19Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5aer]] is a 3 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2you 2you]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AER OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AER FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5aeq|5aeq]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aer FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aer OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5aer RCSB], [http://www.ebi.ac.uk/pdbsum/5aer PDBsum]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/DRD2_HUMAN DRD2_HUMAN]] Myoclonic dystonia 11. The gene represented in this entry may be involved in disease pathogenesis. DRD2 mutations in myoclonic dystonia patients are rare, and their contribution to disease phenotype is unclear (PubMed:10716258). | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NCS1_RAT NCS1_RAT]] Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel.<ref>PMID:17502602</ref> [[http://www.uniprot.org/uniprot/DRD2_HUMAN DRD2_HUMAN]] Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity).<ref>PMID:21645528</ref> <ref>PMID:17264214</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Burgoyne, R]] | ||
| + | [[Category: Derrick, J P]] | ||
[[Category: Karuppiah, V]] | [[Category: Karuppiah, V]] | ||
| + | [[Category: Lian, L Y]] | ||
[[Category: Pandalaneni, S]] | [[Category: Pandalaneni, S]] | ||
| - | [[Category: Lian, L.Y]] | ||
[[Category: Saleem, M]] | [[Category: Saleem, M]] | ||
| - | [[Category: | + | [[Category: Dopamine receptor 2]] |
| - | [[Category: | + | [[Category: Neuronal calcium sensor-1]] |
| + | [[Category: Signaling protein]] | ||
Revision as of 12:53, 18 February 2015
Neuronal calcium sensor-1 (NCS-1)from Rattus norvegicus complex with D2 dopamine receptor peptide from Homo sapiens
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