4tt1
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Crystal structure of fragment 1600-1733 of HSV1 UL36, native== |
| - | + | <StructureSection load='4tt1' size='340' side='right' caption='[[4tt1]], [[Resolution|resolution]] 2.75Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4tt1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TT1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TT1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4tt0|4tt0]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tt1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tt1 RCSB], [http://www.ebi.ac.uk/pdbsum/4tt1 PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DEN_HHV11 DEN_HHV11]] Deneddylase that deregulates the host cell cycle S phase to create a favorable environment allowing efficient viral genome replication. Interacts with and deneddylates host cullins including CUL1 and CUL4A, thereby reducing their E3 ubiquitin ligase activity. Inhibition of cullins leads to the stabilization of cullin-RING ligase substrates such as host CDN1A/p21, CDKN1B/p27kip and CDC25A, preventing S phase progression. Additionally, acts as a deubiquitinase and cleaves both 'Lys-48' and 'Lys-63'-linked ubiquitin chains (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Bressanelli, S]] | [[Category: Bressanelli, S]] | ||
[[Category: Roche, S]] | [[Category: Roche, S]] | ||
[[Category: Scrima, N]] | [[Category: Scrima, N]] | ||
| + | [[Category: Fibrous protein]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Protein fibril]] | ||
| + | [[Category: Tegument protein]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 13:08, 18 February 2015
Crystal structure of fragment 1600-1733 of HSV1 UL36, native
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