UBC13 MMS2
From Proteopedia
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| - | <Structure load='1J7D' size='350' frame='true' align='right' caption='Ubc13 with Mms2' scene='Insert optional scene name here' />==UBC13-MMS2 E2 Complex== | + | <Structure load='1J7D' size='350' frame='true' align='right' caption='Ubc13 with Mms2. Structure determined by Moraes, T.F., Edwards, R.A., McKenna, S., Pastushok, L., Xiao, W., Glover, J.N., Ellison, M.J.' scene='Insert optional scene name here' />==UBC13-MMS2 E2 Complex== |
==Summary== | ==Summary== | ||
Ubc13 is an E2 ubiquitin conjugating enzyme that lacks function without forming a heterodimer with Mms2. Ubc13 is involved in pathways that repair double stranded damage in DNA molecules. When bound to Mms2, Ubc13 will polyubiquinate PCNA, proliferating cell nuclear antigen. Many proteins that Ubc13 interacts with are RING finger proteins such as Traf6. | Ubc13 is an E2 ubiquitin conjugating enzyme that lacks function without forming a heterodimer with Mms2. Ubc13 is involved in pathways that repair double stranded damage in DNA molecules. When bound to Mms2, Ubc13 will polyubiquinate PCNA, proliferating cell nuclear antigen. Many proteins that Ubc13 interacts with are RING finger proteins such as Traf6. | ||
Revision as of 17:27, 21 February 2015
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Contents |
Summary
Ubc13 is an E2 ubiquitin conjugating enzyme that lacks function without forming a heterodimer with Mms2. Ubc13 is involved in pathways that repair double stranded damage in DNA molecules. When bound to Mms2, Ubc13 will polyubiquinate PCNA, proliferating cell nuclear antigen. Many proteins that Ubc13 interacts with are RING finger proteins such as Traf6.
Function
UBC13 functions as a heterodimer with MMS2, a structurally similar protein to UBC13, but lacking the catalytic Cysteine residue in the active site. The UBC13 E2 complex with MMS2 functions primarily to enhance DNA repair from double stranded breaks.
Inhibitors
Coordinating Enzymes
Pathway for DNA Repair
Structural Highlights/Important Residues
Ubc13 weights 17.6 kDA, and Mms2 is 16.8 kDA. The heterodimer is stable at high stalt concentrations (1 M), suggesting strong interactions between the two. Kd between the Ubc13 and Mms2 is 2 uM.
Mechanism
References
Proteopedia Page Contributors and Editors (what is this?)
David A Taves, Michal Harel, Christopher Alexander Hudson, Nicholas R. Dunham
