Ubc9
From Proteopedia
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<StructureSection load='1U9A' size='350' side='right' caption='Human Ubiquitin Conjugating Protein Ubc9 ' scene=''> | <StructureSection load='1U9A' size='350' side='right' caption='Human Ubiquitin Conjugating Protein Ubc9 ' scene=''> | ||
| - | Ubc9 is a ubiquitin-conjugating enzyme (E2) whose function involves transfer of ubiquitin or small ubiquitin-like modifier (SUMO) from activating enzyme (E1) to its designated substrate <ref name="crystal">PMID:9261152</ref>. | + | ''Ubc9'' is a ubiquitin-conjugating enzyme (E2) whose function involves transfer of ubiquitin or small ubiquitin-like modifier (SUMO) from activating enzyme (E1) to its designated substrate <ref name="crystal">PMID:9261152</ref>. |
== Structure == | == Structure == | ||
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== Function == | == Function == | ||
| - | Ubc9 is a part of the SUMOylation process. It is the enzyme responsible for ligating the SUMO to the protein. Depending on whether the reaction is done ''in vitro'', it will ligate the SUMO directly to the substrate, and if done ''in vivo'', the SUMO will be ligated to the conjugating enzyme and then put onto the substrate ^2^. | + | ''Ubc9'' is a part of the SUMOylation process. It is the enzyme responsible for ligating the SUMO to the protein. Depending on whether the reaction is done ''in vitro'', it will ligate the SUMO directly to the substrate, and if done ''in vivo'', the SUMO will be ligated to the conjugating enzyme and then put onto the substrate ^2^. |
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Revision as of 22:14, 24 February 2015
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References
- ↑ 1.0 1.1 Tong H, Hateboer G, Perrakis A, Bernards R, Sixma TK. Crystal structure of murine/human Ubc9 provides insight into the variability of the ubiquitin-conjugating system. J Biol Chem. 1997 Aug 22;272(34):21381-7. PMID:9261152
