4wm7
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wm7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wm7 RCSB], [http://www.ebi.ac.uk/pdbsum/4wm7 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wm7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wm7 RCSB], [http://www.ebi.ac.uk/pdbsum/4wm7 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Enterovirus D68 (EV-D68) is a member of Picornaviridae and is a causative agent of recent outbreaks of respiratory illness in children in the United States. We report here the crystal structures of EV-D68 and its complex with pleconaril, a capsid-binding compound that had been developed as an anti-rhinovirus drug. The hydrophobic drug-binding pocket in viral protein 1 contained density that is consistent with a fatty acid of about 10 carbon atoms. This density could be displaced by pleconaril. We also showed that pleconaril inhibits EV-D68 at a half-maximal effective concentration of 430 nanomolar and might, therefore, be a possible drug candidate to alleviate EV-D68 outbreaks. | ||
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| + | Virus structure. Structure and inhibition of EV-D68, a virus that causes respiratory illness in children.,Liu Y, Sheng J, Fokine A, Meng G, Shin WH, Long F, Kuhn RJ, Kihara D, Rossmann MG Science. 2015 Jan 2;347(6217):71-4. doi: 10.1126/science.1261962. PMID:25554786<ref>PMID:25554786</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 08:24, 25 February 2015
Crystal Structure of Human Enterovirus D68 in Complex with Pleconaril
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Categories: Enterovirus d68 | Fokine, A | Kuhn, R J | Liu, Y | Long, F | Meng, G | Rossmann, M G | Sheng, J | Beta jelly roll | Capsid | Capsid-binding inhibitor | Enterovirus | Virus
