2qag

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[[Image:2qag.gif|left|200px]]<br /><applet load="2qag" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2qag.gif|left|200px]]
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caption="2qag, resolution 4.00&Aring;" />
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'''Crystal structure of human septin trimer 2/6/7'''<br />
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{{Structure
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|PDB= 2qag |SIZE=350|CAPTION= <scene name='initialview01'>2qag</scene>, resolution 4.00&Aring;
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|SITE= <scene name='pdbsite=AC1:Gdp+Binding+Site+For+Residue+A+362'>AC1</scene>, <scene name='pdbsite=AC2:Gtp+Binding+Site+For+Residue+B+428'>AC2</scene> and <scene name='pdbsite=AC3:Gdp+Binding+Site+For+Residue+C+419'>AC3</scene>
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|LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5'-DIPHOSPHATE'>GDP</scene> and <scene name='pdbligand=GTP:GUANOSINE-5'-TRIPHOSPHATE'>GTP</scene>
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|ACTIVITY=
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|GENE= SEPT2, DIFF6, KIAA0158, NEDD5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), SEPT6, KIAA0128, SEP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), SEPT7, CDC10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''Crystal structure of human septin trimer 2/6/7'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2QAG is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=GDP:'>GDP</scene> and <scene name='pdbligand=GTP:'>GTP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Sites: <scene name='pdbsite=AC1:Gdp+Binding+Site+For+Residue+A+362'>AC1</scene>, <scene name='pdbsite=AC2:Gtp+Binding+Site+For+Residue+B+428'>AC2</scene> and <scene name='pdbsite=AC3:Gdp+Binding+Site+For+Residue+C+419'>AC3</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QAG OCA].
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2QAG is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QAG OCA].
==Reference==
==Reference==
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Structural insight into filament formation by mammalian septins., Sirajuddin M, Farkasovsky M, Hauer F, Kuhlmann D, Macara IG, Weyand M, Stark H, Wittinghofer A, Nature. 2007 Sep 20;449(7160):311-5. Epub 2007 Jul 18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17637674 17637674]
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Structural insight into filament formation by mammalian septins., Sirajuddin M, Farkasovsky M, Hauer F, Kuhlmann D, Macara IG, Weyand M, Stark H, Wittinghofer A, Nature. 2007 Sep 20;449(7160):311-5. Epub 2007 Jul 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17637674 17637674]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: structural protein]]
[[Category: structural protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:37:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:23:39 2008''

Revision as of 16:23, 20 March 2008

Image:2qag.gif


PDB ID 2qag

Drag the structure with the mouse to rotate
, resolution 4.00Å
Sites: , and
Ligands: and
Gene: SEPT2, DIFF6, KIAA0158, NEDD5 (Homo sapiens), SEPT6, KIAA0128, SEP2 (Homo sapiens), SEPT7, CDC10 (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



Crystal structure of human septin trimer 2/6/7


Overview

Septins are GTP-binding proteins that assemble into homo- and hetero-oligomers and filaments. Although they have key roles in various cellular processes, little is known concerning the structure of septin subunits or the organization and polarity of septin complexes. Here we present the structures of the human SEPT2 G domain and the heterotrimeric human SEPT2-SEPT6-SEPT7 complex. The structures reveal a universal bipolar polymer building block, composed of an extended G domain, which forms oligomers and filaments by conserved interactions between adjacent nucleotide-binding sites and/or the amino- and carboxy-terminal extensions. Unexpectedly, X-ray crystallography and electron microscopy showed that the predicted coiled coils are not involved in or required for complex and/or filament formation. The asymmetrical heterotrimers associate head-to-head to form a hexameric unit that is nonpolarized along the filament axis but is rotationally asymmetrical. The architecture of septin filaments differs fundamentally from that of other cytoskeletal structures.

About this Structure

2QAG is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural insight into filament formation by mammalian septins., Sirajuddin M, Farkasovsky M, Hauer F, Kuhlmann D, Macara IG, Weyand M, Stark H, Wittinghofer A, Nature. 2007 Sep 20;449(7160):311-5. Epub 2007 Jul 18. PMID:17637674

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