4wsv
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==The crystal structure of hemagglutinin from A/Taiwan/1/2013 in complex with 6'SLN== |
| + | <StructureSection load='4wsv' size='340' side='right' caption='[[4wsv]], [[Resolution|resolution]] 3.10Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4wsv]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WSV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WSV FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wsr|4wsr]], [[4wss|4wss]], [[4wst|4wst]], [[4wsu|4wsu]], [[4wsw|4wsw]], [[4wsx|4wsx]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wsv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wsv RCSB], [http://www.ebi.ac.uk/pdbsum/4wsv PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | During 2013, three new avian influenza A virus subtypes, A(H7N9), A(H6N1) and A(H10N8), resulted in human infections. While the A(H7N9) virus resulted in a significant epidemic in China across 19 provinces and municipalities, both A(H6N1) and A(H10N8) viruses resulted in only a few human infections. This study focuses on the major surface glycoprotein hemagglutinin from both of these novel human viruses. The detailed structural and glycan microarray analyses presented here highlight that both A(H6N1) and A(H10N8) virus hemagglutinins retain a strong avian receptor binding preference, and thus currently pose a low risk for sustained human infections. IMPORTANCE: Human infections with zoonotic influenza virus subtypes continue to be a great public health concern. We report detailed structural analysis and glycan microarray data for recombinant hemagglutinins from A(H6N1) and A(H10N8) viruses, isolated from human infections in 2013, and compare them with hemagglutinins of avian origin. This is the first structural report of an H6 HA, and our results should further the understanding of these viruses, and provide useful information to aid continuous surveillance of these zoonotic influenza viruses. | ||
| - | + | Structure and receptor binding preferences of recombinant hemagglutinins from avian and human H6 and H10 influenza A virus subtypes.,Yang H, Carney PJ, Chang JC, Villanueva JM, Stevens J J Virol. 2015 Feb 11. pii: JVI.03456-14. PMID:25673707<ref>PMID:25673707</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: Villanueva, J | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Carney, P J]] | ||
| + | [[Category: Chang, J C]] | ||
| + | [[Category: Stevens, J]] | ||
| + | [[Category: Villanueva, J M]] | ||
[[Category: Yang, H]] | [[Category: Yang, H]] | ||
| - | [[Category: | + | [[Category: H6]] |
| - | [[Category: | + | [[Category: Hemagglutinin]] |
| - | [[Category: | + | [[Category: Influenza virus]] |
| + | [[Category: Viral protein]] | ||
Revision as of 13:54, 25 February 2015
The crystal structure of hemagglutinin from A/Taiwan/1/2013 in complex with 6'SLN
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