4ove
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==X-ray Crystal Structure of Mouse Netrin-1== |
| - | + | <StructureSection load='4ove' size='340' side='right' caption='[[4ove]], [[Resolution|resolution]] 2.64Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4ove]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OVE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OVE FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ove FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ove OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ove RCSB], [http://www.ebi.ac.uk/pdbsum/4ove PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[ | + | == Function == |
| - | [ | + | [[http://www.uniprot.org/uniprot/NET1_MOUSE NET1_MOUSE]] Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by regulating apoptosis (By similarity). |
| - | [[ | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Koch, M]] | [[Category: Koch, M]] | ||
[[Category: Meier, M]] | [[Category: Meier, M]] | ||
| - | [[Category: Reuten, R]] | ||
| - | [[Category: Orriss, G]] | ||
| - | [[Category: Patel, T.R]] | ||
[[Category: Nikodemus, D]] | [[Category: Nikodemus, D]] | ||
| + | [[Category: Okun, N]] | ||
| + | [[Category: Orriss, G]] | ||
| + | [[Category: Patel, T R]] | ||
| + | [[Category: Reuten, R]] | ||
| + | [[Category: Stetefeld, J]] | ||
| + | [[Category: Apoptosis]] | ||
| + | [[Category: Axon guidance cue]] | ||
| + | [[Category: Dcc]] | ||
| + | [[Category: Domain vi: beta-sandwich jelly-roll]] | ||
| + | [[Category: Domains v-1]] | ||
| + | [[Category: Dscam]] | ||
| + | [[Category: Extracellular matrix]] | ||
| + | [[Category: Neogenin]] | ||
| + | [[Category: Similar to laminin gamma-1]] | ||
| + | [[Category: Structural calcium]] | ||
| + | [[Category: Survival factor]] | ||
| + | [[Category: Unc5a]] | ||
| + | [[Category: Unc5b]] | ||
| + | [[Category: Unc5c]] | ||
| + | [[Category: Unc5d]] | ||
| + | [[Category: V-2]] | ||
| + | [[Category: V-3: laminin-type epidermal growth factor]] | ||
Revision as of 14:01, 25 February 2015
X-ray Crystal Structure of Mouse Netrin-1
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Categories: Koch, M | Meier, M | Nikodemus, D | Okun, N | Orriss, G | Patel, T R | Reuten, R | Stetefeld, J | Apoptosis | Axon guidance cue | Dcc | Domain vi: beta-sandwich jelly-roll | Domains v-1 | Dscam | Extracellular matrix | Neogenin | Similar to laminin gamma-1 | Structural calcium | Survival factor | Unc5a | Unc5b | Unc5c | Unc5d | V-2 | V-3: laminin-type epidermal growth factor
