4ued
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | ''' | + | ==Complex of human EIF4E with the 4E binding protein 4E-BP1== |
| - | + | <StructureSection load='4ued' size='340' side='right' caption='[[4ued]], [[Resolution|resolution]] 1.75Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4ued]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UED OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UED FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ue8|4ue8]], [[4ue9|4ue9]], [[4uea|4uea]], [[4ueb|4ueb]], [[4uec|4uec]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ued FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ued OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ued RCSB], [http://www.ebi.ac.uk/pdbsum/4ued PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[ | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN]] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref> [[http://www.uniprot.org/uniprot/4EBP1_HUMAN 4EBP1_HUMAN]] Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.<ref>PMID:7935836</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Peter, D]] | [[Category: Peter, D]] | ||
[[Category: Weichenrieder, O]] | [[Category: Weichenrieder, O]] | ||
| + | [[Category: 4e binding protein]] | ||
| + | [[Category: Cap binding protein]] | ||
| + | [[Category: Gene regulation]] | ||
| + | [[Category: Translation]] | ||
| + | [[Category: Translational repression]] | ||
Revision as of 14:04, 25 February 2015
Complex of human EIF4E with the 4E binding protein 4E-BP1
| |||||||||||
