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Ectatomin (1eci) is the main component of venom of the ant [https://en.wikipedia.org/wiki/Ectatomma_tuberculatum Ectatomma tuberculatum]. When bitten by E. tuberculatum, Ectatomin inserts into the target's [https://en.wikipedia.org/wiki/Cell_membrane cell membranes] and forms a nonselective [https://en.wikipedia.org/wiki/Ion_channel cation channel]. | Ectatomin (1eci) is the main component of venom of the ant [https://en.wikipedia.org/wiki/Ectatomma_tuberculatum Ectatomma tuberculatum]. When bitten by E. tuberculatum, Ectatomin inserts into the target's [https://en.wikipedia.org/wiki/Cell_membrane cell membranes] and forms a nonselective [https://en.wikipedia.org/wiki/Ion_channel cation channel]. | ||
| - | <scene name='69/691538/Cysteine_disulfide/1'>Disulfide</scene> | ||
== Structure == | == Structure == | ||
| - | Biologically, Ectatomin exists as a heterodimer. | + | Biologically, Ectatomin exists as a heterodimer stabilized by <scene name='69/691538/Cysteine_disulfide/1'>disulfide</scene> linkages. The α subunit has 37 amino acid residues, while the β subunit has 34 amino acid residues. The structure of Ectatomin was solved using 2D NMR and CHARMm computational optimization, though there are 20 similar proposed conformations. |
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| + | Generally, each subunit is composed of two α-helices, linked by disulfide bonds, with a connecting hairpin hinge region. The two subunits are linked by a disfulide bond between their hairpin hinge regions. One α-helix from each subunit is kinked, due to the presence of proline residues. The kinked α-helix of the α subunit is more kinked, containing three proline residues, while the kinked α-helix of the β subunit only contains one proline residue. | ||
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| + | The internal region between the two subunits is primarily composed of hydrophobic residues. | ||
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| + | Sequence - α subunit | ||
| + | GVIPKKIWETVCPTVEPWAKKCSGDIATYIKRECGKL | ||
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| + | Sequence - β subunit | ||
| + | WSTIVKLTICPTLKSMAKKCEGSIATMIKKKCDK | ||
== Mechanism == | == Mechanism == | ||
Revision as of 22:53, 25 February 2015
Ectatomin (1eci)
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