2qfc
From Proteopedia
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| - | [[Image:2qfc.jpg|left|200px]] | + | [[Image:2qfc.jpg|left|200px]] |
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| - | '''Crystal Structure of Bacillus thuringiensis PlcR complexed with PapR''' | + | {{Structure |
| + | |PDB= 2qfc |SIZE=350|CAPTION= <scene name='initialview01'>2qfc</scene>, resolution 2.600Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= plcR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1428 Bacillus thuringiensis]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal Structure of Bacillus thuringiensis PlcR complexed with PapR''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2QFC is a [ | + | 2QFC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bacillus_thuringiensis Bacillus thuringiensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QFC OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of PlcR: Insights into virulence regulation and evolution of quorum sensing in Gram-positive bacteria., Declerck N, Bouillaut L, Chaix D, Rugani N, Slamti L, Hoh F, Lereclus D, Arold ST, Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18490-5. Epub 2007 Nov 12. PMID:[http:// | + | Structure of PlcR: Insights into virulence regulation and evolution of quorum sensing in Gram-positive bacteria., Declerck N, Bouillaut L, Chaix D, Rugani N, Slamti L, Hoh F, Lereclus D, Arold ST, Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18490-5. Epub 2007 Nov 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17998541 17998541] |
[[Category: Bacillus thuringiensis]] | [[Category: Bacillus thuringiensis]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: transcription regulation]] | [[Category: transcription regulation]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:25:18 2008'' |
Revision as of 16:25, 20 March 2008
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| , resolution 2.600Å | |||||||
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| Ligands: | |||||||
| Gene: | plcR (Bacillus thuringiensis) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of Bacillus thuringiensis PlcR complexed with PapR
Overview
Gram-positive bacteria use a wealth of extracellular signaling peptides, so-called autoinducers, to regulate gene expression according to population densities. These "quorum sensing" systems control vital processes such as virulence, sporulation, and gene transfer. Using x-ray analysis, we determined the structure of PlcR, the major virulence regulator of the Bacillus cereus group, and obtained mechanistic insights into the effects of autoinducer binding. Our structural and phylogenetic analysis further suggests that all of those quorum sensors that bind directly to their autoinducer peptide derive from a common ancestor and form a single family (the RNPP family, for Rap/NprR/PlcR/PrgX) with conserved features. As a consequence, fundamentally different processes in different bacterial genera appear regulated by essentially the same autoinducer recognition mechanism. Our results shed light on virulence control by PlcR and elucidate origin and evolution of multicellular behavior in bacteria.
About this Structure
2QFC is a Protein complex structure of sequences from Bacillus thuringiensis. Full crystallographic information is available from OCA.
Reference
Structure of PlcR: Insights into virulence regulation and evolution of quorum sensing in Gram-positive bacteria., Declerck N, Bouillaut L, Chaix D, Rugani N, Slamti L, Hoh F, Lereclus D, Arold ST, Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18490-5. Epub 2007 Nov 12. PMID:17998541
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