4p97
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Functional conservation despite structural divergence in ligand-responsive RNA switches== |
| + | <StructureSection load='4p97' size='340' side='right' caption='[[4p97]], [[Resolution|resolution]] 1.86Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4p97]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P97 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P97 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p97 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p97 RCSB], [http://www.ebi.ac.uk/pdbsum/4p97 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | An internal ribosome entry site (IRES) initiates protein synthesis in RNA viruses, including the hepatitis C virus (HCV). We have discovered ligand-responsive conformational switches in viral IRES elements. Modular RNA motifs of greatly distinct sequence and local secondary structure have been found to serve as functionally conserved switches involved in viral IRES-driven translation and may be captured by identical cognate ligands. The RNA motifs described here constitute a new paradigm for ligand-captured switches that differ from metabolite-sensing riboswitches with regard to their small size, as well as the intrinsic stability and structural definition of the constitutive conformational states. These viral RNA modules represent the simplest form of ligand-responsive mechanical switches in nucleic acids. | ||
| - | + | Functional conservation despite structural divergence in ligand-responsive RNA switches.,Boerneke MA, Dibrov SM, Gu J, Wyles DL, Hermann T Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):15952-7. doi:, 10.1073/pnas.1414678111. Epub 2014 Oct 27. PMID:25349403<ref>PMID:25349403</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | [[Category: Boerneke, M | + | __TOC__ |
| - | [[Category: Dibrov, S | + | </StructureSection> |
| - | [[Category: Hermann, T | + | [[Category: Boerneke, M A]] |
| + | [[Category: Dibrov, S M]] | ||
| + | [[Category: Hermann, T H]] | ||
| + | [[Category: Internal ribosome entry site]] | ||
| + | [[Category: Rna]] | ||
| + | [[Category: Translation]] | ||
| + | [[Category: Viral genome]] | ||
Revision as of 11:22, 4 March 2015
Functional conservation despite structural divergence in ligand-responsive RNA switches
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