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4ppi
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Crystal structure of Bcl-xL hexamer== |
| - | + | <StructureSection load='4ppi' size='340' side='right' caption='[[4ppi]], [[Resolution|resolution]] 2.85Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4ppi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PPI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ppi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ppi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ppi RCSB], [http://www.ebi.ac.uk/pdbsum/4ppi PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[ | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Sreekanth, R]] | [[Category: Sreekanth, R]] | ||
| - | [[Category: Yoon, H | + | [[Category: Yoon, H S]] |
| + | [[Category: 3d domain swap]] | ||
| + | [[Category: Anti-apoptotic]] | ||
| + | [[Category: Apoptosis]] | ||
| + | [[Category: Bcl-2 family]] | ||
Revision as of 11:34, 4 March 2015
Crystal structure of Bcl-xL hexamer
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