4xl1
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Complex of Notch1 (EGF11-13) bound to Delta-like 4 (N-EGF1)== |
| - | + | <StructureSection load='4xl1' size='340' side='right' caption='[[4xl1]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4xl1]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XL1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xl1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xl1 RCSB], [http://www.ebi.ac.uk/pdbsum/4xl1 PDBsum]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: Jude, K | + | == Function == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/NOTC1_RAT NOTC1_RAT]] Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, may function as a receptor for neuronal DNER and may be involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May enhance HIF1A function by sequestering HIF1AN away from HIF1A (By similarity). Acts instructively to control the cell fate determination of CNS multipotent progenitor cells, resulting in astroglial induction and neuron/oligodendrocyte suppression.<ref>PMID:11182080</ref> [[http://www.uniprot.org/uniprot/D3ZHH1_RAT D3ZHH1_RAT]] Putative Notch ligand involved in the mediation of Notch signaling.[RuleBase:RU280815] |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Garcia, K C]] | ||
| + | [[Category: Jude, K M]] | ||
| + | [[Category: Luca, V C]] | ||
| + | [[Category: Egf domain]] | ||
| + | [[Category: Glycosylation]] | ||
| + | [[Category: Protein binding]] | ||
| + | [[Category: Receptor-ligand complex]] | ||
Revision as of 11:39, 4 March 2015
Complex of Notch1 (EGF11-13) bound to Delta-like 4 (N-EGF1)
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