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2qjy

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[[Image:2qjy.jpg|left|200px]]<br /><applet load="2qjy" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2qjy.jpg|left|200px]]
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caption="2qjy, resolution 2.40&Aring;" />
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'''Crystal structure of rhodobacter sphaeroides double mutant with stigmatellin and UQ2'''<br />
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{{Structure
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|PDB= 2qjy |SIZE=350|CAPTION= <scene name='initialview01'>2qjy</scene>, resolution 2.40&Aring;
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|SITE= <scene name='pdbsite=AC1:Bgl+Binding+Site+For+Residue+B+1041'>AC1</scene>, <scene name='pdbsite=AC2:Bgl+Binding+Site+For+Residue+E+1042'>AC2</scene>, <scene name='pdbsite=AC3:Bgl+Binding+Site+For+Residue+G+1043'>AC3</scene>, <scene name='pdbsite=AC4:Bgl+Binding+Site+For+Residue+K+1044'>AC4</scene>, <scene name='pdbsite=AC5:Bgl+Binding+Site+For+Residue+N+1045'>AC5</scene>, <scene name='pdbsite=AC6:Bgl+Binding+Site+For+Residue+P+1046'>AC6</scene>, <scene name='pdbsite=AC7:Sr+Binding+Site+For+Residue+B+1011'>AC7</scene>, <scene name='pdbsite=AC8:Sr+Binding+Site+For+Residue+E+1012'>AC8</scene>, <scene name='pdbsite=AC9:Sr+Binding+Site+For+Residue+H+1013'>AC9</scene>, <scene name='pdbsite=BC1:Sr+Binding+Site+For+Residue+K+1014'>BC1</scene>, <scene name='pdbsite=BC2:Sr+Binding+Site+For+Residue+N+1015'>BC2</scene>, <scene name='pdbsite=BC3:Sr+Binding+Site+For+Residue+Q+1016'>BC3</scene>, <scene name='pdbsite=BC4:Na+Binding+Site+For+Residue+R+2001'>BC4</scene>, <scene name='pdbsite=BC5:Cl+Binding+Site+For+Residue+I+2004'>BC5</scene>, <scene name='pdbsite=BC6:Cl+Binding+Site+For+Residue+R+2005'>BC6</scene>, <scene name='pdbsite=BC7:Hem+Binding+Site+For+Residue+A+501'>BC7</scene>, <scene name='pdbsite=BC8:Hem+Binding+Site+For+Residue+A+502'>BC8</scene>, <scene name='pdbsite=BC9:Hem+Binding+Site+For+Residue+B+301'>BC9</scene>, <scene name='pdbsite=CC1:Fes+Binding+Site+For+Residue+C+200'>CC1</scene>, <scene name='pdbsite=CC2:Hem+Binding+Site+For+Residue+D+501'>CC2</scene>, <scene name='pdbsite=CC3:Hem+Binding+Site+For+Residue+D+502'>CC3</scene>, <scene name='pdbsite=CC4:Hem+Binding+Site+For+Residue+E+301'>CC4</scene>, <scene name='pdbsite=CC5:Fes+Binding+Site+For+Residue+F+200'>CC5</scene>, <scene name='pdbsite=CC6:Hem+Binding+Site+For+Residue+G+501'>CC6</scene>, <scene name='pdbsite=CC7:Hem+Binding+Site+For+Residue+G+502'>CC7</scene>, <scene name='pdbsite=CC8:Hem+Binding+Site+For+Residue+H+301'>CC8</scene>, <scene name='pdbsite=CC9:Fes+Binding+Site+For+Residue+I+200'>CC9</scene>, <scene name='pdbsite=DC1:Hem+Binding+Site+For+Residue+J+501'>DC1</scene>, <scene name='pdbsite=DC2:Hem+Binding+Site+For+Residue+J+502'>DC2</scene>, <scene name='pdbsite=DC3:Hem+Binding+Site+For+Residue+K+301'>DC3</scene>, <scene name='pdbsite=DC4:Fes+Binding+Site+For+Residue+L+200'>DC4</scene>, <scene name='pdbsite=DC5:Hem+Binding+Site+For+Residue+M+501'>DC5</scene>, <scene name='pdbsite=DC6:Hem+Binding+Site+For+Residue+M+502'>DC6</scene>, <scene name='pdbsite=DC7:Hem+Binding+Site+For+Residue+N+301'>DC7</scene>, <scene name='pdbsite=DC8:Fes+Binding+Site+For+Residue+O+200'>DC8</scene>, <scene name='pdbsite=DC9:Hem+Binding+Site+For+Residue+P+501'>DC9</scene>, <scene name='pdbsite=EC1:Hem+Binding+Site+For+Residue+P+502'>EC1</scene>, <scene name='pdbsite=EC2:Hem+Binding+Site+For+Residue+Q+301'>EC2</scene>, <scene name='pdbsite=EC3:Fes+Binding+Site+For+Residue+R+200'>EC3</scene>, <scene name='pdbsite=EC4:Sma+Binding+Site+For+Residue+A+1001'>EC4</scene>, <scene name='pdbsite=EC5:Sma+Binding+Site+For+Residue+D+1002'>EC5</scene>, <scene name='pdbsite=EC6:Sma+Binding+Site+For+Residue+G+1003'>EC6</scene>, <scene name='pdbsite=EC7:Sma+Binding+Site+For+Residue+J+1004'>EC7</scene>, <scene name='pdbsite=EC8:Sma+Binding+Site+For+Residue+M+1005'>EC8</scene>, <scene name='pdbsite=EC9:Sma+Binding+Site+For+Residue+P+1006'>EC9</scene>, <scene name='pdbsite=FC1:Lop+Binding+Site+For+Residue+A+1021'>FC1</scene>, <scene name='pdbsite=FC2:Lop+Binding+Site+For+Residue+D+1022'>FC2</scene>, <scene name='pdbsite=FC3:Lop+Binding+Site+For+Residue+G+1023'>FC3</scene>, <scene name='pdbsite=FC4:Lop+Binding+Site+For+Residue+J+1024'>FC4</scene>, <scene name='pdbsite=FC5:Lop+Binding+Site+For+Residue+M+1025'>FC5</scene>, <scene name='pdbsite=FC6:Lop+Binding+Site+For+Residue+P+1026'>FC6</scene>, <scene name='pdbsite=FC7:Uq2+Binding+Site+For+Residue+A+1101'>FC7</scene>, <scene name='pdbsite=FC8:Uq2+Binding+Site+For+Residue+D+1102'>FC8</scene>, <scene name='pdbsite=FC9:Uq2+Binding+Site+For+Residue+G+1103'>FC9</scene>, <scene name='pdbsite=GC1:Uq2+Binding+Site+For+Residue+J+1104'>GC1</scene>, <scene name='pdbsite=GC2:Uq2+Binding+Site+For+Residue+M+1105'>GC2</scene> and <scene name='pdbsite=GC3:Uq2+Binding+Site+For+Residue+P+1106'>GC3</scene>
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|LIGAND= <scene name='pdbligand=BGL:B-2-OCTYLGLUCOSIDE'>BGL</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SMA:STIGMATELLIN+A'>SMA</scene>, <scene name='pdbligand=LOP:(1R)-2-{[(R)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(DODECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>LOP</scene>, <scene name='pdbligand=UQ2:UBIQUINONE-2'>UQ2</scene> and <scene name='pdbligand=FES:FE2/S2 (INORGANIC) CLUSTER'>FES</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Ubiquinol--cytochrome-c_reductase Ubiquinol--cytochrome-c reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.2.2 1.10.2.2]
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|GENE= petB, fbcB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1063 Rhodobacter sphaeroides]), fbcC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1063 Rhodobacter sphaeroides]), petA, fbcF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1063 Rhodobacter sphaeroides])
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}}
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'''Crystal structure of rhodobacter sphaeroides double mutant with stigmatellin and UQ2'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2QJY is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Rhodobacter_sphaeroides Rhodobacter sphaeroides] with <scene name='pdbligand=BGL:'>BGL</scene>, <scene name='pdbligand=SR:'>SR</scene>, <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=NA:'>NA</scene>, <scene name='pdbligand=HEM:'>HEM</scene>, <scene name='pdbligand=SMA:'>SMA</scene>, <scene name='pdbligand=LOP:'>LOP</scene>, <scene name='pdbligand=UQ2:'>UQ2</scene> and <scene name='pdbligand=FES:'>FES</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Ubiquinol--cytochrome-c_reductase Ubiquinol--cytochrome-c reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.2.2 1.10.2.2] Known structural/functional Sites: <scene name='pdbsite=AC1:Bgl+Binding+Site+For+Residue+B+1041'>AC1</scene>, <scene name='pdbsite=AC2:Bgl+Binding+Site+For+Residue+E+1042'>AC2</scene>, <scene name='pdbsite=AC3:Bgl+Binding+Site+For+Residue+G+1043'>AC3</scene>, <scene name='pdbsite=AC4:Bgl+Binding+Site+For+Residue+K+1044'>AC4</scene>, <scene name='pdbsite=AC5:Bgl+Binding+Site+For+Residue+N+1045'>AC5</scene>, <scene name='pdbsite=AC6:Bgl+Binding+Site+For+Residue+P+1046'>AC6</scene>, <scene name='pdbsite=AC7:Sr+Binding+Site+For+Residue+B+1011'>AC7</scene>, <scene name='pdbsite=AC8:Sr+Binding+Site+For+Residue+E+1012'>AC8</scene>, <scene name='pdbsite=AC9:Sr+Binding+Site+For+Residue+H+1013'>AC9</scene>, <scene name='pdbsite=BC1:Sr+Binding+Site+For+Residue+K+1014'>BC1</scene>, <scene name='pdbsite=BC2:Sr+Binding+Site+For+Residue+N+1015'>BC2</scene>, <scene name='pdbsite=BC3:Sr+Binding+Site+For+Residue+Q+1016'>BC3</scene>, <scene name='pdbsite=BC4:Na+Binding+Site+For+Residue+R+2001'>BC4</scene>, <scene name='pdbsite=BC5:Cl+Binding+Site+For+Residue+I+2004'>BC5</scene>, <scene name='pdbsite=BC6:Cl+Binding+Site+For+Residue+R+2005'>BC6</scene>, <scene name='pdbsite=BC7:Hem+Binding+Site+For+Residue+A+501'>BC7</scene>, <scene name='pdbsite=BC8:Hem+Binding+Site+For+Residue+A+502'>BC8</scene>, <scene name='pdbsite=BC9:Hem+Binding+Site+For+Residue+B+301'>BC9</scene>, <scene name='pdbsite=CC1:Fes+Binding+Site+For+Residue+C+200'>CC1</scene>, <scene name='pdbsite=CC2:Hem+Binding+Site+For+Residue+D+501'>CC2</scene>, <scene name='pdbsite=CC3:Hem+Binding+Site+For+Residue+D+502'>CC3</scene>, <scene name='pdbsite=CC4:Hem+Binding+Site+For+Residue+E+301'>CC4</scene>, <scene name='pdbsite=CC5:Fes+Binding+Site+For+Residue+F+200'>CC5</scene>, <scene name='pdbsite=CC6:Hem+Binding+Site+For+Residue+G+501'>CC6</scene>, <scene name='pdbsite=CC7:Hem+Binding+Site+For+Residue+G+502'>CC7</scene>, <scene name='pdbsite=CC8:Hem+Binding+Site+For+Residue+H+301'>CC8</scene>, <scene name='pdbsite=CC9:Fes+Binding+Site+For+Residue+I+200'>CC9</scene>, <scene name='pdbsite=DC1:Hem+Binding+Site+For+Residue+J+501'>DC1</scene>, <scene name='pdbsite=DC2:Hem+Binding+Site+For+Residue+J+502'>DC2</scene>, <scene name='pdbsite=DC3:Hem+Binding+Site+For+Residue+K+301'>DC3</scene>, <scene name='pdbsite=DC4:Fes+Binding+Site+For+Residue+L+200'>DC4</scene>, <scene name='pdbsite=DC5:Hem+Binding+Site+For+Residue+M+501'>DC5</scene>, <scene name='pdbsite=DC6:Hem+Binding+Site+For+Residue+M+502'>DC6</scene>, <scene name='pdbsite=DC7:Hem+Binding+Site+For+Residue+N+301'>DC7</scene>, <scene name='pdbsite=DC8:Fes+Binding+Site+For+Residue+O+200'>DC8</scene>, <scene name='pdbsite=DC9:Hem+Binding+Site+For+Residue+P+501'>DC9</scene>, <scene name='pdbsite=EC1:Hem+Binding+Site+For+Residue+P+502'>EC1</scene>, <scene name='pdbsite=EC2:Hem+Binding+Site+For+Residue+Q+301'>EC2</scene>, <scene name='pdbsite=EC3:Fes+Binding+Site+For+Residue+R+200'>EC3</scene>, <scene name='pdbsite=EC4:Sma+Binding+Site+For+Residue+A+1001'>EC4</scene>, <scene name='pdbsite=EC5:Sma+Binding+Site+For+Residue+D+1002'>EC5</scene>, <scene name='pdbsite=EC6:Sma+Binding+Site+For+Residue+G+1003'>EC6</scene>, <scene name='pdbsite=EC7:Sma+Binding+Site+For+Residue+J+1004'>EC7</scene>, <scene name='pdbsite=EC8:Sma+Binding+Site+For+Residue+M+1005'>EC8</scene>, <scene name='pdbsite=EC9:Sma+Binding+Site+For+Residue+P+1006'>EC9</scene>, <scene name='pdbsite=FC1:Lop+Binding+Site+For+Residue+A+1021'>FC1</scene>, <scene name='pdbsite=FC2:Lop+Binding+Site+For+Residue+D+1022'>FC2</scene>, <scene name='pdbsite=FC3:Lop+Binding+Site+For+Residue+G+1023'>FC3</scene>, <scene name='pdbsite=FC4:Lop+Binding+Site+For+Residue+J+1024'>FC4</scene>, <scene name='pdbsite=FC5:Lop+Binding+Site+For+Residue+M+1025'>FC5</scene>, <scene name='pdbsite=FC6:Lop+Binding+Site+For+Residue+P+1026'>FC6</scene>, <scene name='pdbsite=FC7:Uq2+Binding+Site+For+Residue+A+1101'>FC7</scene>, <scene name='pdbsite=FC8:Uq2+Binding+Site+For+Residue+D+1102'>FC8</scene>, <scene name='pdbsite=FC9:Uq2+Binding+Site+For+Residue+G+1103'>FC9</scene>, <scene name='pdbsite=GC1:Uq2+Binding+Site+For+Residue+J+1104'>GC1</scene>, <scene name='pdbsite=GC2:Uq2+Binding+Site+For+Residue+M+1105'>GC2</scene> and <scene name='pdbsite=GC3:Uq2+Binding+Site+For+Residue+P+1106'>GC3</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QJY OCA].
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2QJY is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rhodobacter_sphaeroides Rhodobacter sphaeroides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QJY OCA].
==Reference==
==Reference==
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Inhibitor-complexed Structures of the Cytochrome bc1 from the Photosynthetic Bacterium Rhodobacter sphaeroides., Esser L, Elberry M, Zhou F, Yu CA, Yu L, Xia D, J Biol Chem. 2008 Feb 1;283(5):2846-57. Epub 2007 Nov 26. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18039651 18039651]
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Inhibitor-complexed Structures of the Cytochrome bc1 from the Photosynthetic Bacterium Rhodobacter sphaeroides., Esser L, Elberry M, Zhou F, Yu CA, Yu L, Xia D, J Biol Chem. 2008 Feb 1;283(5):2846-57. Epub 2007 Nov 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18039651 18039651]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Rhodobacter sphaeroides]]
[[Category: Rhodobacter sphaeroides]]
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[[Category: oxidoreductase]]
[[Category: oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:39:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:26:39 2008''

Revision as of 16:26, 20 March 2008

Image:2qjy.jpg


PDB ID 2qjy

Drag the structure with the mouse to rotate
, resolution 2.40Å
Sites: , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , and
Ligands: , , , , , , , and
Gene: petB, fbcB (Rhodobacter sphaeroides), fbcC (Rhodobacter sphaeroides), petA, fbcF (Rhodobacter sphaeroides)
Activity: Ubiquinol--cytochrome-c reductase, with EC number 1.10.2.2
Coordinates: save as pdb, mmCIF, xml



Crystal structure of rhodobacter sphaeroides double mutant with stigmatellin and UQ2


Overview

The cytochrome bc(1) complex (bc(1)) is a major contributor to the proton motive force across the membrane by coupling electron transfer to proton translocation. The crystal structures of wild type and mutant bc(1) complexes from the photosynthetic purple bacterium Rhodobacter sphaeroides (Rsbc(1)), stabilized with the quinol oxidation (Q(P)) site inhibitor stigmatellin alone or in combination with the quinone reduction (Q(N)) site inhibitor antimycin, were determined. The high quality electron density permitted assignments of a new metal-binding site to the cytochrome c(1) subunit and a number of lipid and detergent molecules. Structural differences between Rsbc(1) and its mitochondrial counterparts are mostly extra membranous and provide a basis for understanding the function of the predominantly longer sequences in the bacterial subunits. Functional implications for the bc(1) complex are derived from analyses of 10 independent molecules in various crystal forms and from comparisons with mitochondrial complexes.

About this Structure

2QJY is a Protein complex structure of sequences from Rhodobacter sphaeroides. Full crystallographic information is available from OCA.

Reference

Inhibitor-complexed Structures of the Cytochrome bc1 from the Photosynthetic Bacterium Rhodobacter sphaeroides., Esser L, Elberry M, Zhou F, Yu CA, Yu L, Xia D, J Biol Chem. 2008 Feb 1;283(5):2846-57. Epub 2007 Nov 26. PMID:18039651

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