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Beta-lactamase
From Proteopedia
(Difference between revisions)
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*'''β-lactamase class A''' | *'''β-lactamase class A''' | ||
| - | **[[3dtm]], [[1bza]], [[1ck3]], [[1esu]], [[1jwp]], [[1lhy]], [[1li0]], [[1m40]], [[1zg6]], [[2v1z]], [[2v20]], [[3cmz]], [[3jyi]], [[4ibr]], [[4ibx]] - EcBlac A Tem-1 (mutant) - ''Escherichia coli''<br /> | + | **[[3dtm]], [[1bza]], [[1ck3]], [[1esu]], [[1jwp]], [[1lhy]], [[1li0]], [[1m40]], [[1zg6]], [[2v1z]], [[2v20]], [[3cmz]], [[3jyi]], [[4ibr]], [[4ibx]], [[4mez]], [[4rx2]], [[4rx3]] - EcBlac A Tem-1 (mutant) - ''Escherichia coli''<br /> |
| - | **[[1btl]], [[1iys]], [[1xpb]], [[1zg4]], [[4gku]] - EcBlac A Tem-1<br /> | + | **[[1btl]], [[1iys]], [[1xpb]], [[1zg4]], [[4gku]], [[4rva]] - EcBlac A Tem-1<br /> |
**[[1lhy]] - EcBlac A Tem-30 (mutant) <br /> | **[[1lhy]] - EcBlac A Tem-30 (mutant) <br /> | ||
**[[1li0]] - EcBlac A Tem-32 (mutant) <br /> | **[[1li0]] - EcBlac A Tem-32 (mutant) <br /> | ||
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**[[3toi]] - EcBlac A Tem-116 (mutant)<br /> | **[[3toi]] - EcBlac A Tem-116 (mutant)<br /> | ||
**[[4id4]] – EcBlac/PaBlac Tem<br /> | **[[4id4]] – EcBlac/PaBlac Tem<br /> | ||
| - | **[[1we4]], [[2xr0]], [[2zq7]], [[2zq8]], [[2zq9]], [[2zqa]], [[2zqc]], [[2zqd]], [[4bd0]], [[4bd1]] - EcBlac A Toho-1 (mutant) <br /> | + | **[[1we4]], [[2xr0]], [[2zq7]], [[2zq8]], [[2zq9]], [[2zqa]], [[2zqc]], [[2zqd]], [[4bd0]], [[4bd1]], [[4c3k]] - EcBlac A Toho-1 (mutant) <br /> |
**[[2xqz]], [[2wyx]] - EcBlac A Toho-1 (mutant) – Neutron<br /> | **[[2xqz]], [[2wyx]] - EcBlac A Toho-1 (mutant) – Neutron<br /> | ||
**[[3c5a]] – EcBlac A Kpc-2<br /> | **[[3c5a]] – EcBlac A Kpc-2<br /> | ||
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**[[1kge]], [[1kgf]], [[1kgg]], [[1ome]] – SaBlac A (mutant) - S''taphylococcus aureus''<br /> | **[[1kge]], [[1kgf]], [[1kgg]], [[1ome]] – SaBlac A (mutant) - S''taphylococcus aureus''<br /> | ||
**[[3blm]] – SaBlac A<br /> | **[[3blm]] – SaBlac A<br /> | ||
| - | **[[1mbl]], [[3ly3]], [[3soi]] – BlBlac A (mutant) – ''Bacillus licheniformis''<br /> | + | **[[1mbl]], [[3ly3]], [[3soi]], [[4n92]] – BlBlac A (mutant) – ''Bacillus licheniformis''<br /> |
**[[2blm]], [[3sh7]], [[4blm]] – BlBlac A<br /> | **[[2blm]], [[3sh7]], [[4blm]] – BlBlac A<br /> | ||
**[[2cc1]] – Blac A – ''Mycobacterium fortuitum''<br /> | **[[2cc1]] – Blac A – ''Mycobacterium fortuitum''<br /> | ||
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**[[3s4x]] - EncBlac A (mutant) – ''Enterobacter cloacae''<br /> | **[[3s4x]] - EncBlac A (mutant) – ''Enterobacter cloacae''<br /> | ||
**[[3zdj]], [[4b88]] – Blac – precambrian<br /> | **[[3zdj]], [[4b88]] – Blac – precambrian<br /> | ||
| + | **[[4c6y]], [[4c75]] – Blac – synthetic<br /> | ||
*Extended-spectrum β-lactamase class A | *Extended-spectrum β-lactamase class A | ||
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**[[4gog]] - PaESBL A GES-1 + acyl intermediate<br /> | **[[4gog]] - PaESBL A GES-1 + acyl intermediate<br /> | ||
**[[3nia]] - PaESBL A GES-2 + inhibitor<br /> | **[[3nia]] - PaESBL A GES-2 + inhibitor<br /> | ||
| + | **[[4qu3]] - PaESBL A GES-2 + antibiotic<br /> | ||
**[[4gnu]], [[4h8r]] - PaESBL A GES-5<br /> | **[[4gnu]], [[4h8r]] - PaESBL A GES-5<br /> | ||
**[[3v3s]] – PaESBL GES-18<br /> | **[[3v3s]] – PaESBL GES-18<br /> | ||
**[[1e25]] – PaESBL PER-1 (mutant)<br /> | **[[1e25]] – PaESBL PER-1 (mutant)<br /> | ||
| - | **[[ | + | **[[4mx4]], [[4mxg]] – PaESBL Bel-1 <br /> |
| + | **[[4mxb]], [[4mxh]] – PaESBL Bel-1 + antibiotic<br /> | ||
| + | **[[4d2o]] - CfESBL PER-2 – ''Citrobacter freundii''<br /> | ||
| + | **[[3znw]] - CfESBL PER-2 + antribiotic <br /> | ||
**[[3v3r]] - AbESBL A GES-11– ''Acinetobacter baumannii''<br /> | **[[3v3r]] - AbESBL A GES-11– ''Acinetobacter baumannii''<br /> | ||
**[[3tsg]] – AbESBL GES-14<br /> | **[[3tsg]] – AbESBL GES-14<br /> | ||
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**[[3ni9]] - PaESBL A GES-2<br /> | **[[3ni9]] - PaESBL A GES-2<br /> | ||
**[[3g2y]], [[3g2z]], [[3g30]], [[3g31]], [[3g32]], [[3g34]], [[3g35]], [[4dds]], [[4ddy]], [[4de0]], [[4de1]], [[4de2]], [[4de3]] - EcBlac A Ctx-M-9 + inhibitor<br /> | **[[3g2y]], [[3g2z]], [[3g30]], [[3g31]], [[3g32]], [[3g34]], [[3g35]], [[4dds]], [[4ddy]], [[4de0]], [[4de1]], [[4de2]], [[4de3]] - EcBlac A Ctx-M-9 + inhibitor<br /> | ||
| + | **[[4len]] - EcBlac A Ctx-M-9 (mutant) + inhibitor<br /> | ||
**[[3hlw]], [[3huo]], [[3hvf]] - EcBlac A Ctx-M-9 (mutant) + antibiotic<br /> | **[[3hlw]], [[3huo]], [[3hvf]] - EcBlac A Ctx-M-9 (mutant) + antibiotic<br /> | ||
| + | **[[4pm8]] - KpBlac A Ctx-M-14 <br /> | ||
| + | **[[4pm6]], [[4pma]] - KpBlac A Ctx-M-14 (mutant) <br /> | ||
| + | **[[4pm9]] - KpBlac A Ctx-M-14 + antibiotic<br /> | ||
| + | **[[4pm5]], [[4pm7]] - KpBlac A Ctx-M-14 (mutant) + antibiotic<br /> | ||
| + | **[[4s2i]] - KpBlac A Ctx-M-15 + antibiotic<br / | ||
**[[4hbt]] – EcESBL Ctx-M-15<br /> | **[[4hbt]] – EcESBL Ctx-M-15<br /> | ||
**[[4hbu]] – EcESBL Ctx-M-15 + inhibitor<br /> | **[[4hbu]] – EcESBL Ctx-M-15 + inhibitor<br /> | ||
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**[[1erm]], [[1ero]], [[1erq]] – EcBlac A Tem-1 + boronic acid inhibitor<br /> | **[[1erm]], [[1ero]], [[1erq]] – EcBlac A Tem-1 + boronic acid inhibitor<br /> | ||
**[[1jwv]], [[1jwz]] - EcBlac A Tem-1 (mutant) + boronic acid inhibitor<br /> | **[[1jwv]], [[1jwz]] - EcBlac A Tem-1 (mutant) + boronic acid inhibitor<br /> | ||
| - | **[[1ong]], [[1q2p]], [[1vm1]], [[2h5s]], [[2zd8]], [[3d4f]], [[3mke]], [[3mkf]], [[3mxr]], [[3mxs]], [[4fh2]], [[4gd6]], [[4gd8]], [[4gdb]] - KpBlac A Shv-1 + inhibitor<br /> | + | **[[1ong]], [[1q2p]], [[1vm1]], [[2h5s]], [[2zd8]], [[3d4f]], [[3mke]], [[3mkf]], [[3mxr]], [[3mxs]], [[4fh2]], [[4gd6]], [[4gd8]], [[4gdb]], [[4mbf]], [[4r3b]] - KpBlac A Shv-1 + inhibitor<br /> |
| - | **[[1rcj]], [[1tdg]], [[2a49]], [[2h0t]], [[2h0y]], [[2h10]] - KpBlac A Shv-1 (mutant) + inhibitor<br /> | + | **[[1rcj]], [[1tdg]], [[2a49]], [[2h0t]], [[2h0y]], [[2h10]], [[4mbh]], [[4mbk]] - KpBlac A Shv-1 (mutant) + inhibitor<br /> |
**[[3opp]], [[3opr]]- KpBlac A Shv-1 (mutant) + antibiotic<br /> | **[[3opp]], [[3opr]]- KpBlac A Shv-1 (mutant) + antibiotic<br /> | ||
**[[1w7f]], [[3b3x]], [[2y91]], [[4a5r]] - BlBlac A + inhibitor<br /> | **[[1w7f]], [[3b3x]], [[2y91]], [[4a5r]] - BlBlac A + inhibitor<br /> | ||
| - | **[[3m2j]] - BlBlac A (mutant) + inhibitor<br /> | + | **[[3m2j]], [[4n9k]], [[4n9l]] - BlBlac A (mutant) + inhibitor<br /> |
**[[2wk0]], [[2x71]]– BlBlac A + antibiotic<br /> | **[[2wk0]], [[2x71]]– BlBlac A + antibiotic<br /> | ||
**[[3ly4]], [[3m2k]], [[3sh8]], [[3sh9]] - BlBlac A (mutant) + antibiotic<br /> | **[[3ly4]], [[3m2k]], [[3sh8]], [[3sh9]] - BlBlac A (mutant) + antibiotic<br /> | ||
| + | **[[4m3k]], [[4n1h]] - BlBlac A + antibody<br /> | ||
**[[2q9m]], [[2q9n]] - EncBlac A + inhibitor <br /> | **[[2q9m]], [[2q9n]] - EncBlac A + inhibitor <br /> | ||
**[[3bfc]], [[3bff]], [[3bfg]] – CsBlac A Sed-1 (mutant) + inhibitor<br /> | **[[3bfc]], [[3bff]], [[3bfg]] – CsBlac A Sed-1 (mutant) + inhibitor<br /> | ||
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*'''β-lactamase class B (Zn containing)''' | *'''β-lactamase class B (Zn containing)''' | ||
| - | **[[3fcz]], [[3i0v]], [[3i11]], [[3i13]], [[3i14]], [[3i15]], [[1bc2]], [[1bvt]], [[1mqo]], [[2bc2]], [[3bc2]], [[1bmc]] – BcBlac B - ''Bacillus cereus''<br /> | + | **[[3fcz]], [[3i0v]], [[3i11]], [[3i13]], [[3i14]], [[3i15]], [[1bc2]], [[1bvt]], [[1mqo]], [[2bc2]], [[3bc2]], [[1bmc]], [[4c09]], [[4nq4]] – BcBlac B - ''Bacillus cereus''<br /> |
**[[2m5c]] - BcBlac B – NMR<br /> | **[[2m5c]] - BcBlac B – NMR<br /> | ||
**[[3knr]], [[3kns]], [[1dxk]], [[2bfk]], [[2bfl]], [[2bfz]], [[2bg2]], [[2bg6]], [[2bg7]], [[2bg8]], [[2bga]], [[2nxa]], [[2nyp]], [[2nze]], [[2nzf]], [[2uyx]] - BcBlac B (mutant) <br /> | **[[3knr]], [[3kns]], [[1dxk]], [[2bfk]], [[2bfl]], [[2bfz]], [[2bg2]], [[2bg6]], [[2bg7]], [[2bg8]], [[2bga]], [[2nxa]], [[2nyp]], [[2nze]], [[2nzf]], [[2uyx]] - BcBlac B (mutant) <br /> | ||
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**[[1k07]] – FgBlac B - ''Fluoribacter gormanii''<br /> | **[[1k07]] – FgBlac B - ''Fluoribacter gormanii''<br /> | ||
**[[1l9y]] - FgBlac B (mutant) <br /> | **[[1l9y]] - FgBlac B (mutant) <br /> | ||
| - | **[[1ko2]], [[1ko3]] – PaBlac B Vim-2 - ''Pseudomonas aeruginosa''<br /> | + | **[[1ko2]], [[1ko3]], [[4bz3]], [[4nq2]] – PaBlac B Vim-2 - ''Pseudomonas aeruginosa''<br /> |
**[[2whg]], [[2wrs]] - PaBlac B Vim-4<br /> | **[[2whg]], [[2wrs]] - PaBlac B Vim-4<br /> | ||
| + | **[[4d1t]] - PaBlac B Vim-7<br /> | ||
| + | **[[4d1u]], [[4d1v]], [[4d1w]] - PaBlac B Vim-7 (mutant)<br /> | ||
**[[4awy]], [[4awz]] - PaBlac B Aim-1<br /> | **[[4awy]], [[4awz]] - PaBlac B Aim-1<br /> | ||
| + | **[[2ynt]], [[2ynu]], [[2ynv]], [[2ynw]] - PaBlac B Gim-1<br /> | ||
**[[4ax0]], [[4ax1]] - PaBlac B Aim-1 (mutant)<br /> | **[[4ax0]], [[4ax1]] - PaBlac B Aim-1 (mutant)<br /> | ||
**[[2y87]], [[2y8a]], [[2y8b]] - PaBlac B Vim-7<br /> | **[[2y87]], [[2y8a]], [[2y8b]] - PaBlac B Vim-7<br /> | ||
| - | **[[2fhx]] - PaBlac B Spm-1<br /> | + | **[[2fhx]], [[4bp0]] - PaBlac B Spm-1<br /> |
**[[2x01]] - PaBlac Oxa-10 (mutant)<br /> | **[[2x01]] - PaBlac Oxa-10 (mutant)<br /> | ||
**[[2x02]] - PaBlac Oxa-10<br /> | **[[2x02]] - PaBlac Oxa-10<br /> | ||
| + | **[[4uam]] - PaBlac Imp-1 <br /> | ||
**[[4f6h]], [[4f6z]] – PaBlac Imp-1 (mutant)<br /> | **[[4f6h]], [[4f6z]] – PaBlac Imp-1 (mutant)<br /> | ||
**[[1wuo]], [[1wup]] - SmBlac Imp-1 (mutant) – ''Serratia marcescens''<br /> | **[[1wuo]], [[1wup]] - SmBlac Imp-1 (mutant) – ''Serratia marcescens''<br /> | ||
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**[[2yz3]] – Blac Vim-2 – ''Pseudomonas putida''<br /> | **[[2yz3]] – Blac Vim-2 – ''Pseudomonas putida''<br /> | ||
**[[3sd9]] – SfBlac B - ''Serratia fonticola''<br /> | **[[3sd9]] – SfBlac B - ''Serratia fonticola''<br /> | ||
| - | **[[3pg4]] – KpBlac Ndm-1 | + | **[[4ubq]] - AbBlac Imp-2 <br /> |
| + | **[[3pg4]] – KpBlac Ndm-1<br /> | ||
| + | **[[4uwo]], [[4uwp]], [[4uwr]], [[4uws]] - KpBlac B Vim-26<br /> | ||
| + | **[[4wd6]] – Blac Dim-1 – ''Pseudomonas stutzeri''<br /> | ||
*β-lactamase class B binary complex | *β-lactamase class B binary complex | ||
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**[[1a8t]], [[1hlk]], [[1kr3]] - BfBlac B + inhibitor<br /> | **[[1a8t]], [[1hlk]], [[1kr3]] - BfBlac B + inhibitor<br /> | ||
**[[1jt1]] – FgBlac + captopril <br /> | **[[1jt1]] – FgBlac + captopril <br /> | ||
| - | **[[1jje]], [[1jjt]], [[3lce]] - PaBlac B + inhibitor<br /> | + | **[[1jje]], [[1jjt]], [[3lce]], [[3wxc]], [[4c1f]], [[4c1g]] - PaBlac B Imp-1+ inhibitor<br /> |
| + | **[[4c1d]], [[4c1e]], [[4pvo]], [[4pvt]], [[4ua4]] - PaBlac B Vim-2 + inhibitor<br /> | ||
| + | **[[4s2o]] - PaBlac Oxa-10 + antibiotic<br /> | ||
**[[1m2x]] – Blac B + captopril – ''Elizabethkingia meningoseptica''<br /> | **[[1m2x]] – Blac B + captopril – ''Elizabethkingia meningoseptica''<br /> | ||
**[[1vgn]], [[3vqz]] - SmBlac Imp-1+ inhibitor<br /> | **[[1vgn]], [[3vqz]] - SmBlac Imp-1+ inhibitor<br /> | ||
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**[[2qds]] – AhBlac B + captopril<br /> | **[[2qds]] – AhBlac B + captopril<br /> | ||
**[[3m8t]] – BjBlac B + inhibitor<br /> | **[[3m8t]] – BjBlac B + inhibitor<br /> | ||
| - | **[[2m5d]] - BcBlac B + inhibitor<br /> | + | **[[2m5d]], [[4c1c]], [[4c1h]], [[4nq5]], [[4nq6]], [[4nq7]], [[4tyt]] - BcBlac B + inhibitor<br /> |
**[[3q6v]] – SfBlac B + glycerol <br /> | **[[3q6v]] – SfBlac B + glycerol <br /> | ||
**[[3q6x]], [[4ey2]], [[4eyb]], [[4eyf]], [[4efl]], [[4hl1]], [[4hl2]] – KpBlac B Ndm-1+ antibiotic<br /> | **[[3q6x]], [[4ey2]], [[4eyb]], [[4eyf]], [[4efl]], [[4hl1]], [[4hl2]] – KpBlac B Ndm-1+ antibiotic<br /> | ||
| - | **[[4exy]], [[4exs]], [[4eyl]], [[4hky]] – KpBlac B Ndm-1+ inhibitor | + | **[[4exy]], [[4exs]], [[4eyl]], [[4hky]], [[4ram]], [[4raw]], [[4rbs]], [[4rl0]], [[4rl2]], [[4u4l]] – KpBlac B Ndm-1+ inhibitor<br /> |
| + | **[[4rm5]] – KpBlac B Ndm-1 (mutant) + antibiotic<br /> | ||
*'''β-lactamase class C''' | *'''β-lactamase class C''' | ||
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**[[3fkw]], [[3iwi]], [[3iwo]], [[3iwq]], [[3ixd]] – EcBlac C (mutant) <br /> | **[[3fkw]], [[3iwi]], [[3iwo]], [[3iwq]], [[3ixd]] – EcBlac C (mutant) <br /> | ||
**[[1zkj]] – Blac C – ''Enterobacter aerogenes''<br /> | **[[1zkj]] – Blac C – ''Enterobacter aerogenes''<br /> | ||
| - | **[[2qz6]] – Blac C – ''Pseudomonas fluorescens'' | + | **[[2qz6]] – Blac C – ''Pseudomonas fluorescens''<br /> |
| + | **[[3w8k]] – KpBlac C<br /> | ||
| + | **[[4u0t]] – AbBlac C Adc-7<br /> | ||
| + | **[[4qd4]] – AbBlac C Adc-68<br /> | ||
*β-lactamase class C binary complex | *β-lactamase class C binary complex | ||
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**[[1onh]], [[1q2q]], [[1y54]] - EncBlac C + inhibitor<br /> | **[[1onh]], [[1q2q]], [[1y54]] - EncBlac C + inhibitor<br /> | ||
**[[1s6r]] - EncBlac C+ boronic acid inhibitor<br /> | **[[1s6r]] - EncBlac C+ boronic acid inhibitor<br /> | ||
| - | **[[1rgz]] - EncBlac C + | + | **[[1rgz]] - EncBlac C + antibiotic<br /> |
**[1rgy]] - CfBlac C + antibiotic <br /> | **[1rgy]] - CfBlac C + antibiotic <br /> | ||
**[[1zc2]], [[2zc7]] – KpBlac C + inhibitor<br /> | **[[1zc2]], [[2zc7]] – KpBlac C + inhibitor<br /> | ||
**[[2wzx]], [[2wzz]] – PaBlac C + inhibitor<br /> | **[[2wzx]], [[2wzz]] – PaBlac C + inhibitor<br /> | ||
| + | **[[4ooy]] - PaBlac C + antibiotic<br /> | ||
| + | **[[4u0x]] - AbBlac C Adc-7 + boronic acid inhibitor <br /> | ||
*'''β-lactamase class D''' | *'''β-lactamase class D''' | ||
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**[[4mll]] - KpBlac D Oxa-1 + oxacillin<br /> | **[[4mll]] - KpBlac D Oxa-1 + oxacillin<br /> | ||
**[[3hbr]] – KpBlac D Oxa-48<br /> | **[[3hbr]] – KpBlac D Oxa-48<br /> | ||
| - | **[[3if6]] - KpBlac D Oxa-46<br /> | + | **[[4s2j]], [[4s2k]], [[4s2n]], [[4wmc]] - KpBlac D Oxa-48 + antibiotic<br /> |
| + | **[[3if6]], [[4s2p]] - KpBlac D Oxa-46<br /> | ||
**[[4ied]] – Blac – ''Fusobacterium nucleatum''<br /> | **[[4ied]] – Blac – ''Fusobacterium nucleatum''<br /> | ||
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**[[1ke4]], [[2bls]], [[2zj9]], [[3bls]] – EcBlac<br /> | **[[1ke4]], [[2bls]], [[2zj9]], [[3bls]] – EcBlac<br /> | ||
| - | **[[1l0d]], [[1l0e]], [[1l0f]], [[1l0g]] - EcBlac (mutant) | + | **[[1l0d]], [[1l0e]], [[1l0f]], [[1l0g]], [[4kg6]] - EcBlac (mutant) |
**[[1fcn]] – EcBlac (mutant) + substrate<br /> | **[[1fcn]] – EcBlac (mutant) + substrate<br /> | ||
| - | **[[1fco]], [[1i5q]], [[1kvl]] - EcBlac (mutant) + antibiotic<br /> | + | **[[1fco]], [[1i5q]], [[1kvl]], [[4ken]], [[4kg2]], [[4kg5]], [[4kg6]], [[4kz3]], [[4kz4]], [[4kg9]], [[4kz5]], [[4kz6]], [[4kz7]], [[4kz8]], [[4kza]], [[4kzb]] - EcBlac (mutant) + antibiotic<br /> |
| - | **[[1iel]], [[1fcm]], [[1iem]], [[1kvm]], [[1ll5]], [[1ll9]], [[1llb]] - EcBlac + antibiotic<br /> | + | **[[1iel]], [[1fcm]], [[1iem]], [[1kvm]], [[1ll5]], [[1ll9]], [[1llb]], [[4kz3]], [[4kz4]], [[4okp]], [[4olg]] - EcBlac + antibiotic<br /> |
| - | **[[1fsw]], [[1fsy]], [[1kds]], [[1kdw]], [[1ke0]], [[1ke3]], [[1mxo]], [[1my8]], [[4e3i]], [[4e3j]], [[4e3k]], [[4e3l]], [[4e3m]], [[4e3n]], [[4e3o]], [[2i72]] - EcBlac + boronic acid inhibitor<br /> | + | **[[1fsw]], [[1fsy]], [[1kds]], [[1kdw]], [[1ke0]], [[1ke3]], [[1mxo]], [[1my8]], [[4e3i]], [[4e3j]], [[4e3k]], [[4e3l]], [[4e3m]], [[4e3n]], [[4e3o]], [[2i72]], [[4lv0]], [[4lv1]], [[4lv2]], [[4lv3]] - EcBlac + boronic acid inhibitor<br /> |
**[[1pi4]], [[1pi5]], [[2ffy]] - EcBlac (mutant) + boronic acid inhibitor<br /> | **[[1pi4]], [[1pi5]], [[2ffy]] - EcBlac (mutant) + boronic acid inhibitor<br /> | ||
| - | **[[1l2s]], [[1xgi]], [[1xgj]], [[2hdq]], [[2hdr]], [[2hds]], [[2hdu]], [[2p9v]], [[2pu2]], [[2pu4]], [[2r9w]], [[2r9x]], [[2rcx]] - EcBlac + inhibitor<br /> | + | **[[1l2s]], [[1xgi]], [[1xgj]], [[2hdq]], [[2hdr]], [[2hds]], [[2hdu]], [[2p9v]], [[2pu2]], [[2pu4]], [[2r9w]], [[2r9x]], [[2rcx]], [[4jxs]], [[4jxv]], [[4jxw]], [[4old]] - EcBlac + inhibitor<br /> |
| + | **[[4jxg]] – EcBlac + oxacillin<br /> | ||
**[[1o07]] - EcBlac (mutant) + inhibitor<br /> | **[[1o07]] - EcBlac (mutant) + inhibitor<br /> | ||
**[[3s1y]], [[3s22]] - PaBlac (mutant) + inhibitor<br /> | **[[3s1y]], [[3s22]] - PaBlac (mutant) + inhibitor<br /> | ||
| - | **[[4hef]] - PaBlac + inhibitor<br /> | + | **[[4hef]], [[4nk3]] - PaBlac + inhibitor<br /> |
**[[4gzb]] – PaBlac<br /> | **[[4gzb]] – PaBlac<br /> | ||
| + | **[[4net]] – AbBlac<br /> | ||
*'''Carbapenemase''' | *'''Carbapenemase''' | ||
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**[[4jf5]], [[4jf6]] - AbBlac OXA-23 <br /> | **[[4jf5]], [[4jf6]] - AbBlac OXA-23 <br /> | ||
**[[4jf4]] - AbBlac OXA-23 + antibiotic<br /> | **[[4jf4]] - AbBlac OXA-23 + antibiotic<br /> | ||
| + | **[[4oh0]] - AbBlac OXA-58 <br /> | ||
**[[1bue]] – EncBlac<br /> | **[[1bue]] – EncBlac<br /> | ||
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**[[1i2s]] – BlBlac<br /> | **[[1i2s]] – BlBlac<br /> | ||
**[[2gdn]], [[3zhh]] – MtBlac – ''Mycobacterium tuberculosis''<br /> | **[[2gdn]], [[3zhh]] – MtBlac – ''Mycobacterium tuberculosis''<br /> | ||
| + | **[[4whi]] – MtBlac C terminal<br /> | ||
**[[4jlf]] - MtBlac (mutant)<br /> | **[[4jlf]] - MtBlac (mutant)<br /> | ||
**[[3vff]], [[3vfh]], [[4ebl]], [[4ebn]], [[4ebp]] – MtBlac (mutant) + intermediate<br /> | **[[3vff]], [[3vfh]], [[4ebl]], [[4ebn]], [[4ebp]] – MtBlac (mutant) + intermediate<br /> | ||
**[[4df6]] – MtBlac + inhibitor<br /> | **[[4df6]] – MtBlac + inhibitor<br /> | ||
| + | **[[4q8i]], [[4qb8]] – MtBlac + antibiotic<br /> | ||
**[[2jc7]], [[3g4p]] – AbBlac <br /> | **[[2jc7]], [[3g4p]] – AbBlac <br /> | ||
**[[3byd]] – Blac – ''Klebsiella oxytoca''<br /> | **[[3byd]] – Blac – ''Klebsiella oxytoca''<br /> | ||
| Line 242: | Line 275: | ||
**[[4k0w]] – AbBlac Oxa-23 (mutant)<br /> | **[[4k0w]] – AbBlac Oxa-23 (mutant)<br /> | ||
**[[4k0x]] – AbBlac Oxa-23 <br /> | **[[4k0x]] – AbBlac Oxa-23 <br /> | ||
| + | **[[3wrt]] – ChBlac – ''Chromohalobacter''<br /> | ||
| + | **[[3wrz]], [[3ws0]], [[3ws1]], [[3ws2]], [[3ws3]], [[3ws4]], [[3ws5]] – ChBlac (mutant)<br /> | ||
*Other β-lactamase binary complex | *Other β-lactamase binary complex | ||
| Line 255: | Line 290: | ||
**[[3dwz]], [[3iqa]], [[3m6b]], [[3m6h]] – MtBlac + inhibitor<br /> | **[[3dwz]], [[3iqa]], [[3m6b]], [[3m6h]] – MtBlac + inhibitor<br /> | ||
**[[3fv7]], [[3fyz]], [[3fzc]], [[3mbz]] – AbBlac + inhibitor<br /> | **[[3fv7]], [[3fyz]], [[3fzc]], [[3mbz]] – AbBlac + inhibitor<br /> | ||
| + | **[[4wm9]] – AbBlac Oxa-24 + antibiotic <br /> | ||
}} | }} | ||
Revision as of 07:56, 8 March 2015
Beta-lactamase (Blac) are enzymes which make bacteria resistant to β-lactam antibiotics by breaking their β-lactam ring. Blac are classified according to their resistance targets. Class C are cephalosporinases; Class A are broad-spectrum; Class B are metalloenzymes; Class D are cloxacilanases. Carbapenemase (Car) are Blac with wide hydrolytic capacities. Car can hydrolyze penicillins, cephalosporins, monobactams and carbapenems. Extended-spectrum Blac class A (ESBL) hydrolyze penicillins but not cephalosporins.
3D Structures of Beta-lactamase
Updated on 08-March-2015
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Michal Harel, Jaime Prilusky, Alexander Berchansky, Joel L. Sussman
