Botulinum neurotoxin

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(New page: <StructureSection load='3bta' size='340' side='right' caption='Clostridium botulinum neurotoxin type A with cofactor Zn+2 (grey) (PDB code 3bta).' scene=''> '''Botulinum neurotoxin'''...)
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<StructureSection load='3bta' size='340' side='right' caption='Clostridium botulinum neurotoxin type A with cofactor Zn+2 (grey) (PDB code [[3bta]]).' scene=''>
<StructureSection load='3bta' size='340' side='right' caption='Clostridium botulinum neurotoxin type A with cofactor Zn+2 (grey) (PDB code [[3bta]]).' scene=''>
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'''Botulinum neurotoxin''' (CBN) is produced by the bacterium ''Clostridium botulinum''. CBP contains a light and a heavy chains (LC and HC). CBP HC contains two modules: the N-terminal translocation domain and the C-terminal receptor-binding domain. CBP LC proteolyzes SNARE substrates which are essential for synaptic vescicle fusion and neurotransmitter release thus causing paralysis. CBP HC acts as a channel and as transmembrane chaperone enabling the passage of the LC into the cytosol. CBP type A is used by the cosmetics industry for smoothing wrinkles and is known commercially as Botox. For more details see [[Clostridium Botulinum Neurotoxin Type B]].
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'''Botulinum neurotoxin''' (CBN) is produced by the bacterium ''Clostridium botulinum''. CBP contains a light (residues 1-440) and a heavy (resides 441-875) chains (LC and HC). CBP HC contains two modules: the N-terminal translocation domain and the C-terminal receptor-binding domain (residues 876-1296). CBP LC proteolyzes SNARE substrates which are essential for synaptic vescicle fusion and neurotransmitter release thus causing paralysis. CBP HC acts as a channel and as transmembrane chaperone enabling the passage of the LC into the cytosol. CBP type A is used by the cosmetics industry for smoothing wrinkles and is known commercially as Botox. For more details see [[Clostridium Botulinum Neurotoxin Type B]].
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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
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*'''Type A (residues 1-1296)'''
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*'''Type A '''
**[[1s0b]], [[3bta]], [[4ej5]] – CbCBN + Zn – ''Clostridium botulinum'' <br />
**[[1s0b]], [[3bta]], [[4ej5]] – CbCBN + Zn – ''Clostridium botulinum'' <br />
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**[[3v0a]], [[3v0b]] - CbCBN (mutant) + antibody + Type A progenitor toxin + Zn<br />
**[[3v0a]], [[3v0b]] - CbCBN (mutant) + antibody + Type A progenitor toxin + Zn<br />
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*Type A Light Chain (residues 1-416)
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*Type A Light Chain
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**[[2g7k]], [[2g7p]], [[2g7q]], [[2imc]], [[3bwi]], [[3bok]], [[3qix]] - CbCBN LC + Zn<br />
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**[[2g7k]], [[2g7p]], [[2g7q]], [[2imc]], [[3bwi]], [[3bok]], [[3qix]], [[2ise]], [[2isg]], [[2ish]] - CbCBN LC + Zn<br />
**[[3bok]] - CbCBN LC <br />
**[[3bok]] - CbCBN LC <br />
**[[1e1h]], [[1xtf]], [[4kuf]] - CbCBN LC (mutant) + Zn<br />
**[[1e1h]], [[1xtf]], [[4kuf]] - CbCBN LC (mutant) + Zn<br />
**[[3dse]] – CbCBN LC (mutant) + Zn + Ni<br />
**[[3dse]] – CbCBN LC (mutant) + Zn + Ni<br />
**[[1xtg]] - CbCBN LC (mutant) + synaptosomal-associated protein 25 + Zn<br />
**[[1xtg]] - CbCBN LC (mutant) + synaptosomal-associated protein 25 + Zn<br />
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**[[3dda]] - CbCBN LC + synaptosomal-associated protein 25 peptide + Zn<br />
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**[[3dda]], [[3ddb]] - CbCBN LC + synaptosomal-associated protein 25 peptide + Zn<br />
**[[3zur]], [[3zus]] - CbCBN LC/synaptosomal-associated protein 25 translocation domain<br />
**[[3zur]], [[3zus]] - CbCBN LC/synaptosomal-associated protein 25 translocation domain<br />
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**[[2g7n]], [[2ilp]], [[2imb]], [[3qiy]], [[3qiz]], [[3qj0]], [[4hev]] – CbCBN LC + inhibitor + Zn<br />
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**[[2g7n]], [[2ilp]], [[2imb]], [[3qiy]], [[3qiz]], [[3qj0]], [[4hev]], [[2ima]] – CbCBN LC + inhibitor + Zn<br />
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**[[3c88]], [[3c89]], [[3c8a]], [[3c8b]], [[3boo]], [[3qw5]], [[3qw6]], [[3qw7]], [[3qw8]] – CbCBN LC + inhibitor peptide + Zn<br />
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**[[3c88]], [[3c89]], [[3c8a]], [[3c8b]], [[3boo]], [[3qw5]], [[3qw6]], [[3qw7]], [[3qw8]], [[3nf3]] – CbCBN LC + inhibitor peptide + Zn<br />
**[[4ks6]], [[4ktx]] - CbCBN LC (mutant) + inhibitor peptide + Zn<br />
**[[4ks6]], [[4ktx]] - CbCBN LC (mutant) + inhibitor peptide + Zn<br />
**[[3ds9]] – CbCBN LC (mutant) + inhibitor peptide + Zn + Ni<br />
**[[3ds9]] – CbCBN LC (mutant) + inhibitor peptide + Zn + Ni<br />
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**[[3k3q]] - CbCBN LC + antibody + Zn<br />
**[[3k3q]] - CbCBN LC + antibody + Zn<br />
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*Type A receptor-binding domain (residues 876-1296)
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*Type A receptor-binding domain
**[[2vua]], [[3fuo]] – CbPBN <br />
**[[2vua]], [[3fuo]] – CbPBN <br />
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**[[4jra]] – CbCBN + synaptic vesicle glycoprotein 2C<br />
**[[4jra]] – CbCBN + synaptic vesicle glycoprotein 2C<br />
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*Type A Light+Heavy Chains (residues 1-876)
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*Type A Light+Heavy Chains
**[[2w2d]] - CbCBN LC+HC + Zn<br />
**[[2w2d]] - CbCBN LC+HC + Zn<br />
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*'''Type B'''
*'''Type B'''
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**[[1s0b]], [[1s0c]], [[1s0d]], [[1s0e]], [[1s0f]], [[1s0g]], [[1epw]] – CbCBN + Zn<br />
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**[[1s0b]], [[1s0c]], [[1s0d]], [[1s0e]], [[1s0f]], [[1s0g]], [[1epw]], [[1f82]] – CbCBN + Zn<br />
**[[2np0]] – CbCBN + synaptotagmin-2 + Zn<br />
**[[2np0]] – CbCBN + synaptotagmin-2 + Zn<br />
**[[1g9a]], [[1g9b]], [[1g9c]], [[1g9d]] – CbCBN + inhibitor + Zn<br />
**[[1g9a]], [[1g9b]], [[1g9c]], [[1g9d]] – CbCBN + inhibitor + Zn<br />
**[[1i1e]] – CbCBN + doxorubicin + Zn<br />
**[[1i1e]] – CbCBN + doxorubicin + Zn<br />
**[[1f31]] – CbPBN + trisaccharide + Zn<br />
**[[1f31]] – CbPBN + trisaccharide + Zn<br />
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**[[1z0h]] – CbCBN C terminal<br />
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*Type B Light Chain
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**[[2etf]], [[3zuq]] - CbCBN LC + Zn<br />
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*Type B Light+Heavy Chains
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**[[2xhl]] - CbCBN LC+HC + Zn<br />
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*Type B receptor-binding domain
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**[[2nm1]], [[4kbb]] - CbCBN + synaptotagmin-2<br />
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*Type C Light Chain
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**[[2qn0]] - CbCBN LC + Zn<br />
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**[[3deb]] - CbCBN LC (mutant)<br />
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*Type C receptor-binding domain
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**[[3n7k]], [[3r4s]], [[3r4u]] - CbCBN <br />
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*Type D Light Chain
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**[[2fpq]] - CbCBN LC + Zn<br />
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*Type D receptor-binding domain
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**[[3n7j]], [[3obr]], [[3ogg]] - CbCBN <br />
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**[[3rmx]], [[3rmy]] – CbCBN (mutant) <br />
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**[[3obt]] - CbCBN + acetylneuraminic acid<br />
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*Type E
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**[[1t3a]], [[3ffz]] – CbCBN + Zn<br />
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**[[1t3c]], [[1zkw]], [[1zkx]], [[1zl5]], [[1zl6]], [[1zn3]] – CbCBN (mutant) + Zn<br />
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*Type F Light Chain
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**[[2a8a]], [[2a97]] - CbCBN LC + Zn<br />
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**[[3fie]], [[3fii]] - CbCBN LC + Zn + synaptobrevin-2<br />
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*Type F receptor-binding domain
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**[[3rsj]] - CbCBN <br />
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*Type G Light Chain
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**[[1zb7]] - CbCBN LC + Zn<br />
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*Type G receptor-binding domain
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**[[2vxr]], [[3mpp]] - CbCBN <br />
}}
}}
[[Category: Topic Page]]
[[Category: Topic Page]]

Revision as of 07:45, 9 March 2015

Clostridium botulinum neurotoxin type A with cofactor Zn+2 (grey) (PDB code 3bta).

Drag the structure with the mouse to rotate

3D structures of botulinum neurotoxin

Updated on 09-March-2015


References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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