2qqr

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[[Image:2qqr.jpg|left|200px]]<br /><applet load="2qqr" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2qqr.jpg|left|200px]]
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caption="2qqr, resolution 1.80&Aring;" />
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'''JMJD2A hybrid tudor domains'''<br />
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{{Structure
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|PDB= 2qqr |SIZE=350|CAPTION= <scene name='initialview01'>2qqr</scene>, resolution 1.80&Aring;
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|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Residue+A+1'>AC1</scene>, <scene name='pdbsite=AC2:So4+Binding+Site+For+Residue+B+2'>AC2</scene>, <scene name='pdbsite=AC3:So4+Binding+Site+For+Residue+A+3'>AC3</scene>, <scene name='pdbsite=AC4:So4+Binding+Site+For+Residue+B+4'>AC4</scene>, <scene name='pdbsite=AC5:So4+Binding+Site+For+Residue+B+5'>AC5</scene> and <scene name='pdbsite=AC6:So4+Binding+Site+For+Residue+A+6'>AC6</scene>
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|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
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|ACTIVITY=
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|GENE= JMJD2A, JHDM3A, JMJD2, KIAA0677 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''JMJD2A hybrid tudor domains'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2QQR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Sites: <scene name='pdbsite=AC1:So4+Binding+Site+For+Residue+A+1'>AC1</scene>, <scene name='pdbsite=AC2:So4+Binding+Site+For+Residue+B+2'>AC2</scene>, <scene name='pdbsite=AC3:So4+Binding+Site+For+Residue+A+3'>AC3</scene>, <scene name='pdbsite=AC4:So4+Binding+Site+For+Residue+B+4'>AC4</scene>, <scene name='pdbsite=AC5:So4+Binding+Site+For+Residue+B+5'>AC5</scene> and <scene name='pdbsite=AC6:So4+Binding+Site+For+Residue+A+6'>AC6</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QQR OCA].
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2QQR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QQR OCA].
==Reference==
==Reference==
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Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor., Lee J, Thompson JR, Botuyan MV, Mer G, Nat Struct Mol Biol. 2008 Jan;15(1):109-11. Epub 2007 Dec 16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18084306 18084306]
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Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor., Lee J, Thompson JR, Botuyan MV, Mer G, Nat Struct Mol Biol. 2008 Jan;15(1):109-11. Epub 2007 Dec 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18084306 18084306]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: phosphorylation]]
[[Category: phosphorylation]]
[[Category: polymorphism]]
[[Category: polymorphism]]
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[[Category: tandem hybrid tudor domains]]
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[[Category: tandem hybrid tudor domain]]
[[Category: transcription]]
[[Category: transcription]]
[[Category: transcription regulation]]
[[Category: transcription regulation]]
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[[Category: zinc-finger]]
[[Category: zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:41:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:28:37 2008''

Revision as of 16:28, 20 March 2008

Image:2qqr.jpg


PDB ID 2qqr

Drag the structure with the mouse to rotate
, resolution 1.80Å
Sites: , , , , and
Ligands:
Gene: JMJD2A, JHDM3A, JMJD2, KIAA0677 (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



JMJD2A hybrid tudor domains


Overview

The lysine demethylase JMJD2A has the unique property of binding trimethylated peptides from two different histone sequences (H3K4me3 and H4K20me3) through its tudor domains. Here we show using X-ray crystallography and calorimetry that H3K4me3 and H4K20me3, which are recognized with similar affinities by JMJD2A, adopt radically different binding modes, to the extent that we were able to design single point mutations in JMJD2A that inhibited the recognition of H3K4me3 but not H4K20me3 and vice versa.

About this Structure

2QQR is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor., Lee J, Thompson JR, Botuyan MV, Mer G, Nat Struct Mol Biol. 2008 Jan;15(1):109-11. Epub 2007 Dec 16. PMID:18084306

Page seeded by OCA on Thu Mar 20 18:28:37 2008

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