2qr8
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:2qr8.jpg|left|200px]] | + | [[Image:2qr8.jpg|left|200px]] |
| - | + | ||
| - | '''2.0A X-ray structure of C-terminal kinase domain of p90 ribosomal S6 kinase 2 (RSK2)''' | + | {{Structure |
| + | |PDB= 2qr8 |SIZE=350|CAPTION= <scene name='initialview01'>2qr8</scene>, resolution 2.00Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=NA:SODIUM ION'>NA</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] | ||
| + | |GENE= Rps6ka3, Rps6ka-rs1, Rsk2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | ||
| + | }} | ||
| + | |||
| + | '''2.0A X-ray structure of C-terminal kinase domain of p90 ribosomal S6 kinase 2 (RSK2)''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2QR8 is a [ | + | 2QR8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QR8 OCA]. |
==Reference== | ==Reference== | ||
| - | Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2., Malakhova M, Tereshko V, Lee SY, Yao K, Cho YY, Bode A, Dong Z, Nat Struct Mol Biol. 2008 Jan;15(1):112-3. Epub 2007 Dec 16. PMID:[http:// | + | Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2., Malakhova M, Tereshko V, Lee SY, Yao K, Cho YY, Bode A, Dong Z, Nat Struct Mol Biol. 2008 Jan;15(1):112-3. Epub 2007 Dec 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18084304 18084304] |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
| Line 27: | Line 36: | ||
[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:28:47 2008'' |
Revision as of 16:28, 20 March 2008
| |||||||
| , resolution 2.00Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | Rps6ka3, Rps6ka-rs1, Rsk2 (Mus musculus) | ||||||
| Activity: | Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
2.0A X-ray structure of C-terminal kinase domain of p90 ribosomal S6 kinase 2 (RSK2)
Overview
The X-ray structure at 2.0-A resolution of the p90 ribosomal S6 kinase 2 C-terminal kinase domain revealed a C-terminal autoinhibitory alphaL-helix that was embedded in the kinase scaffold and determines the inactive kinase conformation. We suggest a mechanism of activation through displacement of the alphaL-helix and rearrangement of the conserved residue Glu500, as well as the reorganization of the T-loop into the active conformation.
About this Structure
2QR8 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2., Malakhova M, Tereshko V, Lee SY, Yao K, Cho YY, Bode A, Dong Z, Nat Struct Mol Biol. 2008 Jan;15(1):112-3. Epub 2007 Dec 16. PMID:18084304
Page seeded by OCA on Thu Mar 20 18:28:47 2008
