4rd9
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==X-RAY STRUCTURE OF THE APO FORM OF THE AMYLOID PRECURSOR PROTEIN-LIKE PROTEIN 1 (APLP1) E2 DOMAIN== |
| - | + | <StructureSection load='4rd9' size='340' side='right' caption='[[4rd9]], [[Resolution|resolution]] 2.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4rd9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RD9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RD9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rd9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rd9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rd9 RCSB], [http://www.ebi.ac.uk/pdbsum/4rd9 PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | [[ | + | [[http://www.uniprot.org/uniprot/APLP1_HUMAN APLP1_HUMAN]] May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis. |
| - | [[Category: Dahms, S | + | __TOC__ |
| - | [[Category: Than, M | + | </StructureSection> |
| + | [[Category: Dahms, S O]] | ||
| + | [[Category: Than, M E]] | ||
| + | [[Category: Heparin binding]] | ||
| + | [[Category: Sugar binding protein]] | ||
Revision as of 11:56, 11 March 2015
X-RAY STRUCTURE OF THE APO FORM OF THE AMYLOID PRECURSOR PROTEIN-LIKE PROTEIN 1 (APLP1) E2 DOMAIN
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