4yfn
From Proteopedia
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| - | ''' | + | ==Escherichia coli RNA polymerase in complex with squaramide compound 14 (N-[3,4-dioxo-2-(4-{[4-(trifluoromethyl)benzyl]amino}piperidin-1-yl)cyclobut-1-en-1-yl]-3,5-dimethyl-1,2-oxazole-4-sulfonamide)== |
| - | + | <StructureSection load='4yfn' size='340' side='right' caption='[[4yfn]], [[Resolution|resolution]] 3.82Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4yfn]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YFN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YFN FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4C2:N-[3,4-DIOXO-2-(4-{[4-(TRIFLUOROMETHYL)BENZYL]AMINO}PIPERIDIN-1-YL)CYCLOBUT-1-EN-1-YL]-3,5-DIMETHYL-1,2-OXAZOLE-4-SULFONAMIDE'>4C2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4yfk|4yfk]], [[4yfx|4yfx]]</td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yfn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yfn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yfn RCSB], [http://www.ebi.ac.uk/pdbsum/4yfn PDBsum]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Buurman, E | + | == Function == |
| - | [[Category: Eyermann, C | + | [[http://www.uniprot.org/uniprot/RPOZ_ECO24 RPOZ_ECO24]] Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. [[http://www.uniprot.org/uniprot/RPOA_ECO24 RPOA_ECO24]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. [[http://www.uniprot.org/uniprot/RPOC_ECO24 RPOC_ECO24]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. [[http://www.uniprot.org/uniprot/RPOB_ECO24 RPOB_ECO24]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. [[http://www.uniprot.org/uniprot/RPOD_ECOLI RPOD_ECOLI]] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This is the primary sigma factor of this bacterium. |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Fleming, P | + | </StructureSection> |
| + | [[Category: DNA-directed RNA polymerase]] | ||
| + | [[Category: Buurman, E T]] | ||
| + | [[Category: Eyermann, C J]] | ||
| + | [[Category: Ferguson, A D]] | ||
| + | [[Category: Fleming, P R]] | ||
| + | [[Category: Foulk, M A]] | ||
| + | [[Category: Masse, C E]] | ||
| + | [[Category: McKinney, D C]] | ||
[[Category: Molodtsov, V]] | [[Category: Molodtsov, V]] | ||
| - | [[Category: | + | [[Category: Murakami, K S]] |
| - | [[Category: | + | [[Category: Squaramide]] |
| - | [[Category: | + | [[Category: Switch region]] |
| + | [[Category: Transcription-transcription inhibitor complex]] | ||
Revision as of 12:01, 11 March 2015
Escherichia coli RNA polymerase in complex with squaramide compound 14 (N-[3,4-dioxo-2-(4-{[4-(trifluoromethyl)benzyl]amino}piperidin-1-yl)cyclobut-1-en-1-yl]-3,5-dimethyl-1,2-oxazole-4-sulfonamide)
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