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(Difference between revisions)
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==Overall Structure== | ==Overall Structure== | ||
-Monomer | -Monomer | ||
| - | |||
| - | -Crystals contain two molecules of GSK-3beta in the asymmetric unit, and in general the two moleuces are treated as identical unless specified otherwise | ||
-Glycogen Synthase Kinase-3 (GSK-3) is a serine/threonine protein kinase | -Glycogen Synthase Kinase-3 (GSK-3) is a serine/threonine protein kinase | ||
| Line 35: | Line 33: | ||
1)Folding of protein | 1)Folding of protein | ||
a) location and description of position of alpha and beta sheets (Show in separate color on green screen) | a) location and description of position of alpha and beta sheets (Show in separate color on green screen) | ||
| - | b) | + | b) crystal structure data (Table 1, Structural Characterizaiton of the GSK-3B Active Site Using Selective and Non-selective ATP-mimetic Inhibitors) |
2)Substrate binding | 2)Substrate binding | ||
a) “phosphate-binding” pocket: describe three crucial basic residues (Show in different color on green screen) | a) “phosphate-binding” pocket: describe three crucial basic residues (Show in different color on green screen) | ||
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==Credits== | ==Credits== | ||
| - | Introduction - | + | Introduction - Zachary Plourde |
| - | Overall Structure - | + | Overall Structure - Sarah Johnson |
| - | Drug Binding Site - | + | Drug Binding Site - Christina Lincoln |
| - | Additional Features - | + | Additional Features - Bach Pham & Elvan Cevac |
Quiz Question 1 - Nerses Haroutunian | Quiz Question 1 - Nerses Haroutunian | ||
| - | Quiz Question 2 - | + | Quiz Question 2 - Nick H-K |
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 22:32, 12 March 2015
| This Sandbox is Reserved from January 19, 2016, through August 31, 2016 for use for Proteopedia Team Projects by the class Chemistry 423 Biochemistry for Chemists taught by Lynmarie K Thompson at University of Massachusetts Amherst, USA. This reservation includes Sandbox Reserved 425 through Sandbox Reserved 439. |
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