Sandbox Reserved 431
From Proteopedia
(Difference between revisions)
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MTH1 is an enzyme also know as 7,8-dihydro-8-oxoguanine triphosphatase that in the human organism is encoded by the NUDT1 gene. It is inhibited by (S)-Crizotinib which induced an increase in DNA single-strand breaks, activated DNA repair in human colon carcinoma cells, and effectively suppressed tumor growth in animal models. | MTH1 is an enzyme also know as 7,8-dihydro-8-oxoguanine triphosphatase that in the human organism is encoded by the NUDT1 gene. It is inhibited by (S)-Crizotinib which induced an increase in DNA single-strand breaks, activated DNA repair in human colon carcinoma cells, and effectively suppressed tumor growth in animal models. | ||
| - | ==Binding Interactions== | + | ===Binding Interactions=== |
<Structure load='4c9x' size='300' frame='true' align='right' caption='4c9x, (S)-crizotinib in MTH1 Binding Pocket' scene='48/483888/Binding_pocket_and_ligand/1' | <Structure load='4c9x' size='300' frame='true' align='right' caption='4c9x, (S)-crizotinib in MTH1 Binding Pocket' scene='48/483888/Binding_pocket_and_ligand/1' | ||
<br><br> | <br><br> | ||
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- Crizotinib is acts on MTH1 through COMPETATIVE inhibition within the ATP binding pockets of targeted kinases | - Crizotinib is acts on MTH1 through COMPETATIVE inhibition within the ATP binding pockets of targeted kinases | ||
| - | ===Additional Features=== | + | ====Additional Features==== |
<Structure load='1a84' size='300' frame='true' align='right' caption='pdbcode, Insert caption here' scene='Insert optional scene name here' /> | <Structure load='1a84' size='300' frame='true' align='right' caption='pdbcode, Insert caption here' scene='Insert optional scene name here' /> | ||
<br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br> | <br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br> | ||
| - | ====Quiz Question 1==== | + | =====Quiz Question 1===== |
<Structure load='4c9w' size='300' frame='true' align='right' caption='MTH1 protein structure' scene='48/483888/Rainbow_cartoon_1/1' /> | <Structure load='4c9w' size='300' frame='true' align='right' caption='MTH1 protein structure' scene='48/483888/Rainbow_cartoon_1/1' /> | ||
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<br><br><br><br><br> | <br><br><br><br><br> | ||
| - | =====Quiz Question 2===== | + | ======Quiz Question 2====== |
<Structure load='4c9w' size='300' frame='true' align='right' caption='Active Site' scene='outline' /> | <Structure load='4c9w' size='300' frame='true' align='right' caption='Active Site' scene='outline' /> | ||
<scene name='48/483888/Outline/1'>Ligand Close Up</scene> | <scene name='48/483888/Outline/1'>Ligand Close Up</scene> | ||
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-I think here it would be best to show a close up ball and stick of the active site, one with hydrophobic representation, another with charges and one just showing the molecules. | -I think here it would be best to show a close up ball and stick of the active site, one with hydrophobic representation, another with charges and one just showing the molecules. | ||
| - | ======See Also====== | + | =======See Also======= |
*[[MTH1]] (7,8-dihydro-8-oxoguanine triphosphatase) | *[[MTH1]] (7,8-dihydro-8-oxoguanine triphosphatase) | ||
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Quiz Question 2 - Eric Rice | Quiz Question 2 - Eric Rice | ||
| - | =======References======= | + | ========References======== |
[http://www.nature.com/nature/journal/v508/n7495/pdf/nature13194.pdf Stereospecific targeting of MTH1 by | [http://www.nature.com/nature/journal/v508/n7495/pdf/nature13194.pdf Stereospecific targeting of MTH1 by | ||
(S)-crizotinib as an anticancer strategy - Huber] | (S)-crizotinib as an anticancer strategy - Huber] | ||
Revision as of 23:09, 12 March 2015
| This Sandbox is Reserved from January 19, 2016, through August 31, 2016 for use for Proteopedia Team Projects by the class Chemistry 423 Biochemistry for Chemists taught by Lynmarie K Thompson at University of Massachusetts Amherst, USA. This reservation includes Sandbox Reserved 425 through Sandbox Reserved 439. |
Contents |
Format Help
***We may want to consider changing our pdb code to 4c9x rather than 4c9w. The only difference between them is which enantiomer of crizotinib MTH1 is binding to. 4c9w = R and 4c9x = S. The S enantiomer is the one that causes inhibition. --Matt
OurMolecule
Introduction
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This is a sample scene created with SAT to by Group, and another to make of the protein.
MTH1, also known as 7,8-dihydro-8-oxoguanine triphosphatase is an enzyme in the human body encodet by the NUDT1 gene.
MTH1 is an enzyme also know as 7,8-dihydro-8-oxoguanine triphosphatase that in the human organism is encoded by the NUDT1 gene. It is inhibited by (S)-Crizotinib which induced an increase in DNA single-strand breaks, activated DNA repair in human colon carcinoma cells, and effectively suppressed tumor growth in animal models.
Binding Interactions
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