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2qts

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[[Image:2qts.jpg|left|200px]]<br /><applet load="2qts" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2qts.jpg|left|200px]]
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caption="2qts, resolution 1.900&Aring;" />
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'''Structure of an acid-sensing ion channel 1 at 1.9 A resolution and low pH'''<br />
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{{Structure
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|PDB= 2qts |SIZE=350|CAPTION= <scene name='initialview01'>2qts</scene>, resolution 1.900&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> and <scene name='pdbligand=CL:CHLORIDE ION'>CL</scene>
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|ACTIVITY=
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|GENE= ACCN2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus])
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}}
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'''Structure of an acid-sensing ion channel 1 at 1.9 A resolution and low pH'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2QTS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with <scene name='pdbligand=MAL:'>MAL</scene>, <scene name='pdbligand=NAG:'>NAG</scene> and <scene name='pdbligand=CL:'>CL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QTS OCA].
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2QTS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QTS OCA].
==Reference==
==Reference==
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Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH., Jasti J, Furukawa H, Gonzales EB, Gouaux E, Nature. 2007 Sep 20;449(7160):316-23. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17882215 17882215]
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Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH., Jasti J, Furukawa H, Gonzales EB, Gouaux E, Nature. 2007 Sep 20;449(7160):316-23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17882215 17882215]
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: trimer]]
[[Category: trimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:42:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:29:32 2008''

Revision as of 16:29, 20 March 2008

Image:2qts.jpg


PDB ID 2qts

Drag the structure with the mouse to rotate
, resolution 1.900Å
Ligands: , and
Gene: ACCN2 (Gallus gallus)
Coordinates: save as pdb, mmCIF, xml



Structure of an acid-sensing ion channel 1 at 1.9 A resolution and low pH


Overview

Acid-sensing ion channels (ASICs) are voltage-independent, proton-activated receptors that belong to the epithelial sodium channel/degenerin family of ion channels and are implicated in perception of pain, ischaemic stroke, mechanosensation, learning and memory. Here we report the low-pH crystal structure of a chicken ASIC1 deletion mutant at 1.9 A resolution. Each subunit of the chalice-shaped homotrimer is composed of short amino and carboxy termini, two transmembrane helices, a bound chloride ion and a disulphide-rich, multidomain extracellular region enriched in acidic residues and carboxyl-carboxylate pairs within 3 A, suggesting that at least one carboxyl group bears a proton. Electrophysiological studies on aspartate-to-asparagine mutants confirm that these carboxyl-carboxylate pairs participate in proton sensing. Between the acidic residues and the transmembrane pore lies a disulphide-rich 'thumb' domain poised to couple the binding of protons to the opening of the ion channel, thus demonstrating that proton activation involves long-range conformational changes.

About this Structure

2QTS is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.

Reference

Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH., Jasti J, Furukawa H, Gonzales EB, Gouaux E, Nature. 2007 Sep 20;449(7160):316-23. PMID:17882215

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