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Introduction

This scene is of the within the Kappa Opioid Receptor by Group 3.

-"Kappa-Opioid receptors mediate the regulation of pain, respiratory drive, mood"
-"structure reveals important features of the ligand-binding pocket that contribute to the high affinity and subtype selectivity of JDTic for the human kappa-OR"
-consequences of stress as well as depression/anxiety
-hallucinogenic effects
-talk about mu and kappa OR
-intro to kappa-OR subtype selectivity

Overall Structure

Binding Interactions

Active Site of kappa Opioid Receptors

Common Ligands of Opioid Receptors

 Agonists - Mechanisms, Structure, and Effects
    Salvinorin A
    Morphine

 Antagonists - Mechanisms, Structure, and Effects
    JDTic
    Naloxone

Additional Features

Quiz Question 1

-include some basic structure of , maybe show charge distribution
- Where are the binding sites of the opioid receptor (OR why are the binding sites located here in jmol), and what conformational changes does the protein undergo while binding to ligands? What kinds of functional groups would opioids have that interact with these sites, enabling binding?

Quiz Question 2

What properties would a substrate binding to the active site of the Kappa-opioid receptor probably possess? Explain your reasoning.

See Also

• UvrABC
• Opioid Receptor
• Mu Opioid Receptor Bound to a Morphinan Antagonist
• G protein-coupled Receptor

Credits

Introduction - Patrick Harney

Overall Structure - Matthew Long

Drug Binding Site - Brandon Kittredge

Additional Features - Jacob Kellet

Quiz Question 1 - Leah Caffrey

Quiz Question 2 - Bridget Kilkenny

References