2qu4
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:2qu4.jpg|left|200px]] | + | [[Image:2qu4.jpg|left|200px]] |
| - | + | ||
| - | '''Model for Bacterial ParM Filament''' | + | {{Structure |
| + | |PDB= 2qu4 |SIZE=350|CAPTION= <scene name='initialview01'>2qu4</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Model for Bacterial ParM Filament''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2QU4 is a [ | + | 2QU4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QU4 OCA]. |
==Reference== | ==Reference== | ||
| - | The structure of bacterial ParM filaments., Orlova A, Garner EC, Galkin VE, Heuser J, Mullins RD, Egelman EH, Nat Struct Mol Biol. 2007 Oct;14(10):921-6. Epub 2007 Sep 16. PMID:[http:// | + | The structure of bacterial ParM filaments., Orlova A, Garner EC, Galkin VE, Heuser J, Mullins RD, Egelman EH, Nat Struct Mol Biol. 2007 Oct;14(10):921-6. Epub 2007 Sep 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17873883 17873883] |
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 26: | Line 35: | ||
[[Category: structural protein]] | [[Category: structural protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:29:35 2008'' |
Revision as of 16:29, 20 March 2008
| |||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Model for Bacterial ParM Filament
Overview
Bacterial ParM is a homolog of eukaryotic actin and is involved in moving plasmids so that they segregate properly during cell division. Using cryo-EM and three-dimensional reconstruction, we show that ParM filaments have a different structure from F-actin, with very different subunit-subunit interfaces. These interfaces result in the helical handedness of the ParM filament being opposite to that of F-actin. Like F-actin, ParM filaments have a variable twist, and we show that this involves domain-domain rotations within the ParM subunit. The present results yield new insights into polymorphisms within F-actin, as well as the evolution of polymer families.
About this Structure
2QU4 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
The structure of bacterial ParM filaments., Orlova A, Garner EC, Galkin VE, Heuser J, Mullins RD, Egelman EH, Nat Struct Mol Biol. 2007 Oct;14(10):921-6. Epub 2007 Sep 16. PMID:17873883
Page seeded by OCA on Thu Mar 20 18:29:35 2008
