Cocaine esterase
From Proteopedia
(Difference between revisions)
| Line 16: | Line 16: | ||
**[[3i2j]], [[3puh]] - RhCocE – ''Rhodococcus''<br /> | **[[3i2j]], [[3puh]] - RhCocE – ''Rhodococcus''<br /> | ||
| - | **[[1l7r]], [[3pui]] - RhCocE (mutant) | + | **[[1l7r]], [[3pui]], [[4p08]] - RhCocE (mutant) |
*Cocaine esterase binary complex | *Cocaine esterase binary complex | ||
Revision as of 10:12, 16 March 2015
Cocaine esterase (CocE) catalyzes the hydrolysis of the benzoyl ester of cocaine to ecgonine methyl ester and benzoic acid. CocE contains 3 domains. Domain 1 contains the catalytic triad: Ser, Asp and His typical of the hydrolase family. Domains 2 and 3 are involved in substrate recognition. CocE is produced by bacteria which thrive in soil of cocaine-producing plants. These bacteria use cocaine as their sole source of carbon and nitrogen. CocE is being investigated as a possible therapeutic agent for treatment of cocaine abuse.
3D structures of cocaine esterase
Updated on 16-March-2015
