CXC chemokine receptor

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Revision as of 10:03, 18 March 2015

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spinqualitylabelsall models Human CXCR4/lysozyme chimera complex with antagonist citrulline (PDB code 3oe0) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image CXC chemokine receptors bind to cytokines of the CXC chemokine family. CXC chemokine receptor type 4 (CXCR4) is specific for Stromal Derived Factor 1 (SDF-1α, known also as CXCL12). The CXRC4 is used by HIV to infect CD4+ T cells. The biological unit probably is a [1]. This image based on 3oe0. CXCR1 recognizes CXC chemokines with ELR amino acids adjacent to the CXC motif.

3D Structures of CXCR4

Updated on 18-March-2015

1. ↑ Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V, Abagyan R, Brooun A, Wells P, Bi FC, Hamel DJ, Kuhn P, Handel TM, Cherezov V, Stevens RC. Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists. Science. 2010 Oct 7. PMID:20929726 doi:10.1126/science.1194396