2qwy

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[[Image:2qwy.jpg|left|200px]]<br /><applet load="2qwy" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2qwy.jpg|left|200px]]
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caption="2qwy, resolution 2.80&Aring;" />
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'''SAM-II riboswitch bound to S-adenosylmethionine'''<br />
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{{Structure
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|PDB= 2qwy |SIZE=350|CAPTION= <scene name='initialview01'>2qwy</scene>, resolution 2.80&Aring;
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|SITE= <scene name='pdbsite=AC1:Po4+Binding+Site+For+Residue+A+0'>AC1</scene>, <scene name='pdbsite=AC2:Po4+Binding+Site+For+Residue+B+0'>AC2</scene>, <scene name='pdbsite=AC3:Po4+Binding+Site+For+Residue+B+53'>AC3</scene>, <scene name='pdbsite=AC4:Po4+Binding+Site+For+Residue+C+53'>AC4</scene>, <scene name='pdbsite=AC5:Mg+Binding+Site+For+Residue+A+102'>AC5</scene>, <scene name='pdbsite=AC6:Cs+Binding+Site+For+Residue+A+101'>AC6</scene>, <scene name='pdbsite=AC7:Cs+Binding+Site+For+Residue+C+501'>AC7</scene>, <scene name='pdbsite=AC8:Sam+Binding+Site+For+Residue+A+100'>AC8</scene>, <scene name='pdbsite=AC9:Sam+Binding+Site+For+Residue+B+300'>AC9</scene> and <scene name='pdbsite=BC1:Sam+Binding+Site+For+Residue+C+500'>BC1</scene>
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|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''SAM-II riboswitch bound to S-adenosylmethionine'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2QWY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=CS:'>CS</scene>, <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=SAM:'>SAM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Sites: <scene name='pdbsite=AC1:Po4+Binding+Site+For+Residue+A+0'>AC1</scene>, <scene name='pdbsite=AC2:Po4+Binding+Site+For+Residue+B+0'>AC2</scene>, <scene name='pdbsite=AC3:Po4+Binding+Site+For+Residue+B+53'>AC3</scene>, <scene name='pdbsite=AC4:Po4+Binding+Site+For+Residue+C+53'>AC4</scene>, <scene name='pdbsite=AC5:Mg+Binding+Site+For+Residue+A+102'>AC5</scene>, <scene name='pdbsite=AC6:Cs+Binding+Site+For+Residue+A+101'>AC6</scene>, <scene name='pdbsite=AC7:Cs+Binding+Site+For+Residue+C+501'>AC7</scene>, <scene name='pdbsite=AC8:Sam+Binding+Site+For+Residue+A+100'>AC8</scene>, <scene name='pdbsite=AC9:Sam+Binding+Site+For+Residue+B+300'>AC9</scene> and <scene name='pdbsite=BC1:Sam+Binding+Site+For+Residue+C+500'>BC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QWY OCA].
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2QWY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QWY OCA].
==Reference==
==Reference==
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Structure of the SAM-II riboswitch bound to S-adenosylmethionine., Gilbert SD, Rambo RP, Van Tyne D, Batey RT, Nat Struct Mol Biol. 2008 Feb;15(2):177-82. Epub 2008 Jan 20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18204466 18204466]
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Structure of the SAM-II riboswitch bound to S-adenosylmethionine., Gilbert SD, Rambo RP, Van Tyne D, Batey RT, Nat Struct Mol Biol. 2008 Feb;15(2):177-82. Epub 2008 Jan 20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18204466 18204466]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Batey, R T.]]
[[Category: Batey, R T.]]
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[[Category: sam]]
[[Category: sam]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:43:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:30:31 2008''

Revision as of 16:30, 20 March 2008

Image:2qwy.jpg


PDB ID 2qwy

Drag the structure with the mouse to rotate
, resolution 2.80Å
Sites: , , , , , , , , and
Ligands: , , and
Coordinates: save as pdb, mmCIF, xml



SAM-II riboswitch bound to S-adenosylmethionine


Overview

In bacteria, numerous genes harbor regulatory elements in the 5' untranslated regions of their mRNA, termed riboswitches, which control gene expression by binding small-molecule metabolites. These sequences influence the secondary and tertiary structure of the RNA in a ligand-dependent manner, thereby directing its transcription or translation. The crystal structure of an S-adenosylmethionine-responsive riboswitch found predominantly in proteobacteria, SAM-II, has been solved to reveal a second means by which RNA interacts with this important cellular metabolite. Notably, this is the first structure of a complete riboswitch containing all sequences associated with both the ligand binding aptamer domain and the regulatory expression platform. Chemical probing of this RNA in the absence and presence of ligand shows how the structure changes in response to S-adenosylmethionine to sequester the ribosomal binding site and affect translational gene regulation.

About this Structure

2QWY is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.

Reference

Structure of the SAM-II riboswitch bound to S-adenosylmethionine., Gilbert SD, Rambo RP, Van Tyne D, Batey RT, Nat Struct Mol Biol. 2008 Feb;15(2):177-82. Epub 2008 Jan 20. PMID:18204466

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