2qzd
From Proteopedia
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| - | [[Image:2qzd.gif|left|200px]] | + | [[Image:2qzd.gif|left|200px]] |
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| - | '''Fitted structure of SCR4 of DAF into cryoEM density''' | + | {{Structure |
| + | |PDB= 2qzd |SIZE=350|CAPTION= <scene name='initialview01'>2qzd</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= CD55, CR, DAF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''Fitted structure of SCR4 of DAF into cryoEM density''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2QZD is a [ | + | 2QZD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QZD OCA]. |
==Reference== | ==Reference== | ||
| - | Interaction of decay-accelerating factor with coxsackievirus B3., Hafenstein S, Bowman VD, Chipman PR, Bator Kelly CM, Lin F, Medof ME, Rossmann MG, J Virol. 2007 Dec;81(23):12927-35. Epub 2007 Sep 5. PMID:[http:// | + | Interaction of decay-accelerating factor with coxsackievirus B3., Hafenstein S, Bowman VD, Chipman PR, Bator Kelly CM, Lin F, Medof ME, Rossmann MG, J Virol. 2007 Dec;81(23):12927-35. Epub 2007 Sep 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17804498 17804498] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: sushi]] | [[Category: sushi]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:31:06 2008'' |
Revision as of 16:31, 20 March 2008
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| Gene: | CD55, CR, DAF (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Fitted structure of SCR4 of DAF into cryoEM density
Contents |
Overview
Many entero-, parecho-, and rhinoviruses use immunoglobulin (Ig)-like receptors that bind into the viral canyon and are required to initiate viral uncoating during infection. However, some of these viruses use an alternative or additional receptor that binds outside the canyon. Both the coxsackievirus-adenovirus receptor (CAR), an Ig-like molecule that binds into the viral canyon, and decay-accelerating factor (DAF) have been identified as cellular receptors for coxsackievirus B3 (CVB3). A cryoelectron microscopy reconstruction of a variant of CVB3 complexed with DAF shows full occupancy of the DAF receptor in each of 60 binding sites. The DAF molecule bridges the canyon, blocking the CAR binding site and causing the two receptors to compete with one another. The binding site of DAF on CVB3 differs from the binding site of DAF on the surface of echoviruses, suggesting independent evolutionary processes.
Disease
Known diseases associated with this structure: Blood group Cromer OMIM:[125240], Blood group, Knops system OMIM:[120620], CR1 deficiency OMIM:[120620], Malaria, severe, resistance to OMIM:[120620], SLE susceptibility OMIM:[120620]
About this Structure
2QZD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Interaction of decay-accelerating factor with coxsackievirus B3., Hafenstein S, Bowman VD, Chipman PR, Bator Kelly CM, Lin F, Medof ME, Rossmann MG, J Virol. 2007 Dec;81(23):12927-35. Epub 2007 Sep 5. PMID:17804498
Page seeded by OCA on Thu Mar 20 18:31:06 2008
Categories: Homo sapiens | Single protein | Bowman, V D. | Chipman, P R. | Hafenstein, S. | Kelly, C M.Bator. | Lin, F. | Medof, M E. | Rossmann, M G. | Alternative splicing | Blood group antigen | Complement pathway | Glycoprotein | Gpi-anchor | Immune response | Immune system | Innate immunity | Lipoprotein | Membrane | Polymorphism | Scr4 of daf from 1ojv fitted into cryoem density | Sushi
