4yea

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m (Protected "4yea" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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==Crystal structure of cisplatin bound to a human copper chaperone (dimer) - new refinement==
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<StructureSection load='4yea' size='340' side='right' caption='[[4yea]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4yea]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YEA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YEA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3iwx|3iwx]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yea OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yea RCSB], [http://www.ebi.ac.uk/pdbsum/4yea PDBsum]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/ATOX1_HUMAN ATOX1_HUMAN]] Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Copper trafficking proteins, including the chaperone Atox1 and the P(1B)-type ATPase ATP7B, have been implicated in cellular resistance to the anticancer drug cisplatin. We have determined two crystal structures of cisplatin-Atox1 adducts that reveal platinum coordination by the conserved CXXC copper-binding motif. Direct interaction of cisplatin with this functionally relevant site has significant implications for understanding the molecular basis for resistance mediated by copper transport pathways.
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The entry 4yea is ON HOLD
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Crystal structures of cisplatin bound to a human copper chaperone.,Boal AK, Rosenzweig AC J Am Chem Soc. 2009 Oct 14;131(40):14196-7. PMID:19807176<ref>PMID:19807176</ref>
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Authors: Shabalin, I.G., Boal, A.K., Dauter, Z., Jaskolski, M., Minor, W., Rosenzweig, A.C., Wlodawer, A.
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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Description: Crystal structure of cisplatin bound to a human copper chaperone (dimer) -new refinement
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Dauter, Z]]
[[Category: Dauter, Z]]
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[[Category: Rosenzweig, A.C]]
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[[Category: Jaskolski, M]]
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[[Category: Minor, W]]
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[[Category: Shabalin, I G]]
[[Category: Wlodawer, A]]
[[Category: Wlodawer, A]]
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[[Category: Boal, A.K]]
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[[Category: Cisplatin]]
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[[Category: Minor, W]]
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[[Category: Metal transport]]
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[[Category: Shabalin, I.G]]
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[[Category: Metal-binding]]
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[[Category: Jaskolski, M]]
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[[Category: Platinum]]
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[[Category: Re-refinement of 3iwx]]

Revision as of 11:59, 18 March 2015

Crystal structure of cisplatin bound to a human copper chaperone (dimer) - new refinement

4yea, resolution 2.14Å

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