2r18
From Proteopedia
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| - | [[Image:2r18.jpg|left|200px]] | + | [[Image:2r18.jpg|left|200px]] |
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| - | '''Structural insights into the multifunctional protein VP3 of Birnaviruses''' | + | {{Structure |
| + | |PDB= 2r18 |SIZE=350|CAPTION= <scene name='initialview01'>2r18</scene>, resolution 2.300Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''Structural insights into the multifunctional protein VP3 of Birnaviruses''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2R18 is a [ | + | 2R18 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Infectious_bursal_disease_virus Infectious bursal disease virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R18 OCA]. |
==Reference== | ==Reference== | ||
| - | Structural insights into the multifunctional protein VP3 of birnaviruses., Casanas A, Navarro A, Ferrer-Orta C, Gonzalez D, Rodriguez JF, Verdaguer N, Structure. 2008 Jan;16(1):29-37. PMID:[http:// | + | Structural insights into the multifunctional protein VP3 of birnaviruses., Casanas A, Navarro A, Ferrer-Orta C, Gonzalez D, Rodriguez JF, Verdaguer N, Structure. 2008 Jan;16(1):29-37. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18184581 18184581] |
[[Category: Infectious bursal disease virus]] | [[Category: Infectious bursal disease virus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: virion]] | [[Category: virion]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:31:39 2008'' |
Revision as of 16:31, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structural insights into the multifunctional protein VP3 of Birnaviruses
Overview
Infectious bursal disease virus (IBDV), a member of the Birnaviridae family, is the causative agent of one of the most harmful poultry diseases. The IBDV genome encodes five mature proteins; of these, the multifunctional protein VP3 plays an essential role in virus morphogenesis. This protein, which interacts with the structural protein VP2, with the double-stranded RNA genome, and with the virus-encoded, RNA-dependent RNA polymerase, VP1, is involved not only in the formation of the viral capsid, but also in the recruitment of VP1 into the capsid and in the encapsidation of the viral genome. Here, we report the X-ray structure of the central region of VP3, residues 92-220, consisting of two alpha-helical domains connected by a long and flexible hinge that are organized as a dimer. Unexpectedly, the overall fold of the second VP3 domain shows significant structural similarities with different transcription regulation factors.
About this Structure
2R18 is a Single protein structure of sequence from Infectious bursal disease virus. Full crystallographic information is available from OCA.
Reference
Structural insights into the multifunctional protein VP3 of birnaviruses., Casanas A, Navarro A, Ferrer-Orta C, Gonzalez D, Rodriguez JF, Verdaguer N, Structure. 2008 Jan;16(1):29-37. PMID:18184581
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