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4mqa
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Human beta-tryptase co-crystal structure with {(1,1,3,3-tetramethyldisiloxane-1,3-diyl)bis[5-(methylsulfanyl)benzene-3,1-diyl]}bis({4-[3-(aminomethyl)phenyl]piperidin-1-yl}methanone)== |
| - | + | <StructureSection load='4mqa' size='340' side='right' caption='[[4mqa]], [[Resolution|resolution]] 2.25Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4mqa]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MQA FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=X00:{(1,1,3,3-TETRAMETHYLDISILOXANE-1,3-DIYL)BIS[5-(METHYLSULFANYL)BENZENE-3,1-DIYL]}BIS({4-[3-(AMINOMETHYL)PHENYL]PIPERIDIN-1-YL}METHANONE)'>X00</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mpu|4mpu]], [[4mpv|4mpv]], [[4mpw|4mpw]], [[4mpx|4mpx]]</td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptase Tryptase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.59 3.4.21.59] </span></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mqa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mqa RCSB], [http://www.ebi.ac.uk/pdbsum/4mqa PDBsum]</span></td></tr> |
| - | [[ | + | </table> |
| - | [[Category: | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/TRYB1_HUMAN TRYB1_HUMAN]] Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Tryptase]] | ||
[[Category: Lakshminarasimhan, D]] | [[Category: Lakshminarasimhan, D]] | ||
| + | [[Category: Suto, R]] | ||
| + | [[Category: White, A]] | ||
| + | [[Category: Alpha-hydroxyketone]] | ||
| + | [[Category: Coferon]] | ||
| + | [[Category: Crystal catalysis]] | ||
| + | [[Category: Drug discovery]] | ||
| + | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
| + | [[Category: Self-assembly]] | ||
| + | [[Category: Silanol]] | ||
| + | [[Category: Small molecule inhibitor]] | ||
Revision as of 12:10, 18 March 2015
Human beta-tryptase co-crystal structure with {(1,1,3,3-tetramethyldisiloxane-1,3-diyl)bis[5-(methylsulfanyl)benzene-3,1-diyl]}bis({4-[3-(aminomethyl)phenyl]piperidin-1-yl}methanone)
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