5afv
From Proteopedia
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| - | ''' | + | ==Pharmacophore-based virtual screening to discover new active compounds for human choline kinase alpha1.== |
| - | + | <StructureSection load='5afv' size='340' side='right' caption='[[5afv]], [[Resolution|resolution]] 2.25Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5afv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AFV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AFV FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JH5:1-BENZYL-4-(BENZYLAMINO)-1H-1,2,4-TRIAZOL-4-IUM'>JH5</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5afv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5afv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5afv RCSB], [http://www.ebi.ac.uk/pdbsum/5afv PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[ | + | == Function == |
| - | [[ | + | [[http://www.uniprot.org/uniprot/CHKA_HUMAN CHKA_HUMAN]] Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.<ref>PMID:19915674</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Entrena, A]] | [[Category: Entrena, A]] | ||
| - | [[Category: Gallo Mezo, M.A]] | ||
| - | [[Category: Serran-Aguilera, L]] | ||
| - | [[Category: Nuti, R]] | ||
[[Category: Hurtado-Guerrero, R]] | [[Category: Hurtado-Guerrero, R]] | ||
| + | [[Category: Lopez-Cara, L C]] | ||
[[Category: Macchiarulo, A]] | [[Category: Macchiarulo, A]] | ||
| + | [[Category: Mezo, M A.Gallo]] | ||
| + | [[Category: Nuti, R]] | ||
| + | [[Category: Serran-Aguilera, L]] | ||
| + | [[Category: Pharmacophore]] | ||
| + | [[Category: Transferase]] | ||
| + | [[Category: Virtual screening]] | ||
Revision as of 12:19, 18 March 2015
Pharmacophore-based virtual screening to discover new active compounds for human choline kinase alpha1.
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