C-X-C motif chemokine

From Proteopedia

proteopedia linkproteopedia link

Revision as of 09:54, 23 November 2014 (edit) Michal Harel (Talk | contribs) ← Previous diff		Revision as of 11:40, 19 March 2015 (edit) (undo) Michal Harel (Talk | contribs) Next diff →
Line 18:		Line 18:
	**[[3n52]] – mCXCL – mouse<br />		**[[3n52]] – mCXCL – mouse<br />
	**[[1mi2]] – mCXCL – NMR<br />		**[[1mi2]] – mCXCL – NMR<br />
		+
		+	*CXCL5
		+
		+	**[[2mgs]] – hCXCL – human – NMR<br />
	*CXCL10		*CXCL10
-	**[[1lv9]] – hCXCL – human – NMR<br />	+	**[[1lv9]] – hCXCL – NMR<br />
	**[[1o7z]], [[1o7y]], [[1o80]] – hCXCL<br />		**[[1o7z]], [[1o7y]], [[1o80]] – hCXCL<br />
	**[[2r3z]] – mCXCL <br />		**[[2r3z]] – mCXCL <br />

---

Revision as of 11:40, 19 March 2015

spinqualitylabelsall models PDB ID 1qg7 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
CXCL12α dimer complex with sulfate, 1qg7
Ligands:
Structural annotation: Resources: CATH : 1Qg7A00, 1Qg7B00 InterPro : Ipr002473, Ipr001089, Ipr001811 Pfam : PF00048 SCOP : d1qg7a_, d1qg7b_ UniProt : P48061
Functional annotation: Cellular component: extracellular region extracellular space Biological process: chemotaxis G-protein coupled receptor protein signaling pathway cellular calcium ion homeostasis regulation of actin polymerization and/or depolymerization blood circulation response to virus cell-cell signaling cell adhesion immune response signal transduction inflammatory response Molecular function: receptor binding cytokine activity chemokine activity growth factor activity signal transducer activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml

C-X-C motif chemokine (CXCL) are small chemokines.

• CXCL2 or MIP-2 or imacrophage inflammatory protein 2 acts as chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells.
• CXCL10 or IP-10 or interferon γ-induced protein 10 acts as chemoattractant for monocytes, T cells NK cells and dendritic cells. CXCL10 binds to the cell surface receptor CXCR3.
• CXCL11 or IP-9 or interferon γ-induced protein 9 acts as chemotactic for activated T cells.
• CXCL12 or Stromal-Derived-Factor-1 (SDF1) has a role in angiogenesis, tumor metastasis and the migration of cells from the liver to the bone marrow during embryogenesis.
• CXCL14 or BRAK acts as chemotactic for monocytes and inhibits angiogenesis.

3D Structures of C-X-C motif chemokine

Updated on 19-March-2015