2r9r

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[[Image:2r9r.jpg|left|200px]]<br /><applet load="2r9r" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2r9r.jpg|left|200px]]
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caption="2r9r, resolution 2.40&Aring;" />
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'''Shaker family voltage dependent potassium channel (kv1.2-kv2.1 paddle chimera channel) in association with beta subunit'''<br />
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{{Structure
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|PDB= 2r9r |SIZE=350|CAPTION= <scene name='initialview01'>2r9r</scene>, resolution 2.40&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene> and <scene name='pdbligand=PGW:(1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate'>PGW</scene>
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|ACTIVITY=
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|GENE= Kcnab2, Ckbeta2, Kcnb3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]), kcna2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
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}}
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'''Shaker family voltage dependent potassium channel (kv1.2-kv2.1 paddle chimera channel) in association with beta subunit'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2R9R is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=K:'>K</scene>, <scene name='pdbligand=NAP:'>NAP</scene> and <scene name='pdbligand=PGW:'>PGW</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9R OCA].
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2R9R is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9R OCA].
==Reference==
==Reference==
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Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment., Long SB, Tao X, Campbell EB, MacKinnon R, Nature. 2007 Nov 15;450(7168):376-82. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18004376 18004376]
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Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment., Long SB, Tao X, Campbell EB, MacKinnon R, Nature. 2007 Nov 15;450(7168):376-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18004376 18004376]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: voltage-gated channel]]
[[Category: voltage-gated channel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:45:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:33:51 2008''

Revision as of 16:33, 20 March 2008

Image:2r9r.jpg


PDB ID 2r9r

Drag the structure with the mouse to rotate
, resolution 2.40Å
Ligands: , and
Gene: Kcnab2, Ckbeta2, Kcnb3 (Rattus norvegicus), kcna2 (Rattus norvegicus)
Coordinates: save as pdb, mmCIF, xml



Shaker family voltage dependent potassium channel (kv1.2-kv2.1 paddle chimera channel) in association with beta subunit


Overview

Voltage-dependent K+ (Kv) channels repolarize the action potential in neurons and muscle. This type of channel is gated directly by membrane voltage through protein domains known as voltage sensors, which are molecular voltmeters that read the membrane voltage and regulate the pore. Here we describe the structure of a chimaeric voltage-dependent K+ channel, which we call the 'paddle-chimaera channel', in which the voltage-sensor paddle has been transferred from Kv2.1 to Kv1.2. Crystallized in complex with lipids, the complete structure at 2.4 angstrom resolution reveals the pore and voltage sensors embedded in a membrane-like arrangement of lipid molecules. The detailed structure, which can be compared directly to a large body of functional data, explains charge stabilization within the membrane and suggests a mechanism for voltage-sensor movements and pore gating.

About this Structure

2R9R is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment., Long SB, Tao X, Campbell EB, MacKinnon R, Nature. 2007 Nov 15;450(7168):376-82. PMID:18004376

Page seeded by OCA on Thu Mar 20 18:33:51 2008

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