2rai

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[[Image:2rai.jpg|left|200px]]<br /><applet load="2rai" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2rai.jpg|left|200px]]
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caption="2rai, resolution 3.20&Aring;" />
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'''The PX-BAR membrane remodeling unit of Sorting Nexin 9'''<br />
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{{Structure
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|PDB= 2rai |SIZE=350|CAPTION= <scene name='initialview01'>2rai</scene>, resolution 3.20&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= SNX9, SH3PX1, SH3PXD3A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''The PX-BAR membrane remodeling unit of Sorting Nexin 9'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2RAI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RAI OCA].
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2RAI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RAI OCA].
==Reference==
==Reference==
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The PX-BAR membrane-remodeling unit of sorting nexin 9., Pylypenko O, Lundmark R, Rasmuson E, Carlsson SR, Rak A, EMBO J. 2007 Nov 14;26(22):4788-800. Epub 2007 Oct 18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17948057 17948057]
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The PX-BAR membrane-remodeling unit of sorting nexin 9., Pylypenko O, Lundmark R, Rasmuson E, Carlsson SR, Rak A, EMBO J. 2007 Nov 14;26(22):4788-800. Epub 2007 Oct 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17948057 17948057]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: tubulation]]
[[Category: tubulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:45:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:34:06 2008''

Revision as of 16:34, 20 March 2008

Image:2rai.jpg


PDB ID 2rai

Drag the structure with the mouse to rotate
, resolution 3.20Å
Gene: SNX9, SH3PX1, SH3PXD3A (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



The PX-BAR membrane remodeling unit of Sorting Nexin 9


Overview

Sorting nexins (SNXs) form a family of proteins known to interact with components in the endosomal system and to regulate various steps of vesicle transport. Sorting nexin 9 (SNX9) is involved in the late stages of clathrin-mediated endocytosis in non-neuronal cells, where together with the GTPase dynamin, it participates in the formation and scission of the vesicle neck. We report here crystal structures of the functional membrane-remodeling unit of SNX9 and show that it efficiently tubulates lipid membranes in vivo and in vitro. Elucidation of the protein superdomain structure, together with mutational analysis and biochemical and cell biological experiments, demonstrated how the SNX9 PX and BAR domains work in concert in targeting and tubulation of phosphoinositide-containing membranes. The study provides insights into the SNX9-induced membrane modulation mechanism.

About this Structure

2RAI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The PX-BAR membrane-remodeling unit of sorting nexin 9., Pylypenko O, Lundmark R, Rasmuson E, Carlsson SR, Rak A, EMBO J. 2007 Nov 14;26(22):4788-800. Epub 2007 Oct 18. PMID:17948057

Page seeded by OCA on Thu Mar 20 18:34:06 2008

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