Sandbox Reserved 1058
From Proteopedia
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=='''Isocitrate Lyase from ''Mycobacterium tuberculosis'''''== | =='''Isocitrate Lyase from ''Mycobacterium tuberculosis'''''== | ||
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| + | ===Relevance=== | ||
| + | Mycobacterium tuberculosis is a respiratory infection that causes numerous fatalities throughout the world. | ||
| + | It lives in organisms and feeds off of host cells, which indicate a variety of lipases exist within M. tuberculosis. Current drugs that are on the market now target a small number of bacterial processes like cell wall formation and chromosomal replication. Although several antibiotics exist, all of them target these same mechanisms of inhibition. These commonalities have led to the prevalence of different multi-drug resistant (MDR) tuberculosis strains. Due to the high level of resistance, finding a lasting treatment for MDR TB infections has become very problematic. Studies into new mechanisms of inhibition will be crucial to prevent widespread outbreaks. | ||
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===Wild Type Protein=== | ===Wild Type Protein=== | ||
===3-Bromopyruvate=== | ===3-Bromopyruvate=== | ||
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== Disease == | == Disease == | ||
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| - | == Relevance == | ||
== Structural highlights == | == Structural highlights == | ||
Revision as of 17:21, 27 March 2015
Contents |
Isocitrate Lyase from Mycobacterium tuberculosis
Relevance
Mycobacterium tuberculosis is a respiratory infection that causes numerous fatalities throughout the world. It lives in organisms and feeds off of host cells, which indicate a variety of lipases exist within M. tuberculosis. Current drugs that are on the market now target a small number of bacterial processes like cell wall formation and chromosomal replication. Although several antibiotics exist, all of them target these same mechanisms of inhibition. These commonalities have led to the prevalence of different multi-drug resistant (MDR) tuberculosis strains. Due to the high level of resistance, finding a lasting treatment for MDR TB infections has become very problematic. Studies into new mechanisms of inhibition will be crucial to prevent widespread outbreaks.
Wild Type Protein
3-Bromopyruvate
3-Nitopropionate
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